CD160 cDNA ORF Clone, Mouse, C-DYKDDDDK (Flag®) tag

CD16 antigen, also known as Natural killer cell receptor BY55 and CD16, is a cell membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. CD16 is a GPI-anchored lymphocyte surface receptor in which expression is mostly restricted to the highly cytotoxic CD56(dim)CD16(+) peripheral blood NK subset. CD16 is a receptor showing broad specificity for both classical and non-classical MHC class I molecules. CD16 is expressed in spleen, peripheral blood, and small intestine. Expression of CD16 is restricted to functional NK and T cytotoxic lymphocytes. CD16 acts as a co-activator receptor for CD3-induced proliferation of CD4+ CD16+ T cells isolated from inflammatory skin lesions. Unique CD4+ CD16+ lymphocyte subset may play a role in the pathogenesis of skin inflammation. Activated NK lymphocytes release a soluble form of CD16 that functionally impairs the MHC-I-specific cytotoxic CD8(+) T lymphocyte responsiveness.

• Cancer Immunotherapy
• Co-inhibitory Immune Checkpoint Targets
• Immune Checkpoint
• Immune Checkpoint Detection: Antibodies
• Immune Checkpoint Detection: ELISA Antibodies
• Immune Checkpoint Detection: FCM Antibodies
• Immune Checkpoint Detection: IHC Antibodies
• Immune Checkpoint Targets
• Immunotherapy
• Targeted Therapy

CD160 molecule

• Barakonyi A. et al., 2004, J Immunol.173 (9): 5349-54.
• Rabot M. et al., 2006, Transpl Immunol. 17 (1): 36-8.
• Abecassis S. et al., 2007, J Invest Dermatol. 127?(5): 1161-6.
• Giustiniani J.?et al., 2007, J Immunol. 178 (3): 1293-300.