CXCL7 cDNA ORF Clone, Human, C-His tag

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CXCL7 cDNA ORF Clone, Human, C-His tag: General Information

Gene
Species
Human
NCBI Ref Seq
RefSeq ORF Size
387 bp
Description
Full length Clone DNA of Human pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) with C terminal His tag.
Plasmid
Promoter
Enhanced CMV promoter
Vector
Tag Sequence
His Tag Sequence: CACCATCACCACCATCATCACCACCATCAC
Sequencing Primers
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Kanamycin
Antibiotic in Mammalian cell
Hygromycin
Application
Stable or Transient mammalian expression
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.

Citation List

CXCL7 cDNA ORF Clone, Human, C-His tag: Synonyms

B-TG1 cDNA ORF Clone, Human; Beta-TG cDNA ORF Clone, Human; CTAP-III cDNA ORF Clone, Human; CTAP3 cDNA ORF Clone, Human; CTAPIII cDNA ORF Clone, Human; CXCL7 cDNA ORF Clone, Human; LA-PF4 cDNA ORF Clone, Human; LDGF cDNA ORF Clone, Human; MDGF cDNA ORF Clone, Human; NAP-2 cDNA ORF Clone, Human; PBP cDNA ORF Clone, Human; SCYB7 cDNA ORF Clone, Human; TC1 cDNA ORF Clone, Human; TC2 cDNA ORF Clone, Human; TGB cDNA ORF Clone, Human; TGB1 cDNA ORF Clone, Human; THBGB cDNA ORF Clone, Human; THBGB1 cDNA ORF Clone, Human

CXCL7 Background Information

Pro-platelet basic protein (PPBP) is also known as Chemokine (C-X-C motif) ligand 7 (CXCL7) and nucleosome assembly protein (Nap-2). Nap-2 / PPBP / CXCL7 is released in large amounts from platelets following their activation and is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. Nap-2 / PPBP / CXCL7 has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. Nap-2 is a ligand for CXCR1 and CXCR2, and Nap-2, Nap-2 (73), Nap-2 (74), Nap-2 (1-66), and most potent Nap-2 (1-63) are chemoattractants and activators for neutrophils.
Full Name
pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
References
  • Walz A, et al. (1989) Effects of the neutrophil-activating peptide NAP-2, platelet basic protein, connective tissue-activating peptide III and platelet factor 4 on human neutrophils. J Exp Med. 170(5):1745-50.
  • Walz A, et al. (1990) Generation of the neutrophil-activating peptide NAP-2 from platelet basic protein or connective tissue-activating peptide III through monocyte proteases. J Exp Med. 171(2): 449-54.
  • Loetscher P, et al. (1994) Both interleukin-8 receptors independently mediate chemotaxis. Jurkat cells transfected with IL-8R1 or IL-8R2 migrate in response to IL-8, GRO alpha and NAP-2. FEBS Lett. 341(2-3): 187-92.
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