The plasmid is confirmed by full-length sequencing.
Antibiotic in E.coli
Antibiotic in Mammalian cell
Stable or Transient mammalian expression
Storage & Shipping
Each tube contains lyophilized plasmid.
The lyophilized plasmid can be stored at ambient temperature for three months.
CALB2 cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
Calretinin (CALB2) is a member of the EF-hand family of Ca(2+)-binding proteins and is expressed in a majority of poorly differentiated colon carcinoma and additionally in mesothelioma of the epithelioid and mixed type. Calretinin (CALB2) is a diagnostic marker for epithelioid mesothelioma. It is also a prognostic marker since patients with tumors expressing high calretinin levels have better overall survival. Silencing of calretinin decreases the viability of epithelioid mesothelioma cells. The calcium-binding protein calretinin (CALB2) is currently considered the most sensitive and specific marker for the diagnosis of malignant mesothelioma (MM). Calretinin (CALB2) is a diagnostic and prognostic marker in malignant pleural mesothelioma (MPM).
Kresoja-Rakic J, et al. (2016) Identification of cis- and trans-acting elements regulating calretinin expression in mesothelioma cells. Oncotarget 7 (16): 21272-21286.
Häner K, et al. (2010) A bipartite butyrate-responsive element in the human calretinin (calb2) promoter acts as a repressor in colon carcinoma cells but not in mesothelioma cells. J Cell Biochem 109 (3): 519-531.
Blum W, et al. (2018) Regulation of calretinin in malignant mesothelioma is mediated by septin 7 binding to the calb2 promoter. BMC Cancer 18 (1): 475.
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