Anti-SELL / CD62L Antibody

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Anti-SELL / CD62L Antibody (Rabbit Monoclonal antibody) General Information

Product name
Anti-SELL / CD62L Antibody
Validated applications
IHC-P
Species reactivity
Reacts with: Mouse
Specificity
Mouse SELL / CD62L
Immunogen
Recombinant Mouse CD62L / L-Selectin / SELL Protein (Catalog#50045-M08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD62L / L-Selectin / SELL (rM CD62L / L-Selectin / SELL; Catalog#50045-M08H; NP_035476.1; Met1-Asn332).
Source
Monoclonal Rabbit IgG Clone #122
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-SELL / CD62L Antibody (Rabbit Monoclonal antibody) Validated Applications

Application Dilution
IHC-P 1:100-1:500
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-SELL / CD62L Antibody (Rabbit Monoclonal antibody) Images

Immunochemical staining of mouse SELL in mouse spleen with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections).

Anti-SELL / CD62L Antibody: Alternative Names

Anti-AI528707 Antibody; Anti-CD62L Antibody; Anti-L-selectin Antibody; Anti-LECAM-1 Antibody; Anti-Lnhr Antibody; Anti-Ly-22 Antibody; Anti-Ly-m22 Antibody; Anti-Lyam-1 Antibody; Anti-Lyam1 Antibody

SELL / CD62L Background Information

L-selectin (SELL), also known as CD62L, is a key adhesion molecule that regulates both the migration of leukocytes at sites of inflammation and the recirculation of lymphocytes between blood and lymphoid tissues. It belongs to the selectin family of proteins, and consisting of a large, highly glycosylated, extracellular domain, a single spanning transmembrane domain and a small cytoplasmic tail. L-selectin is the only selectin expressed on leukocytes and mediates a number of leukocyte-endothelial interactions. L-selectin acts as a "homing receptor" for leukocytes to enter secondary lymphoid tissues via high endothelial venules. Ligands present on endothelial cells will bind to leukocyte expressing L-selectin, slowing leukocyte trafficking through the blood, and facilitating entry into a secondary lymphoid organ at that point. L-selectin-mediated lymphocyte recirculation is required for maintaining the appropriate tissue distribution of lymphocyte subpopulations including naïve and effector subsets such as regulatory T cells. In addition, L-selectin-mediated entry into peripheral lymph nodes is required for optimal induction of lymphocyte homeostatic proliferation during lymphopenia. Importantly, L-selectin has been shown to have both adhesive and signaling functions during leukocyte migration. L-selectin has also been shown to mediate leukocyte recruitment during chronic inflammatory and autoimmune diseases and thus is a potential therapeutic target for drug development.
Full Name
selectin L
References
  • Smalley DM, et al. (2005) L-selectin: mechanisms and physiological significance of ectodomain cleavage. J Cell Mol Med. 9(2): 255-66.
  • Grailer JJ, et al. (2009) L-selectin: role in regulating homeostasis and cutaneous inflammation. J Dermatol Sci. 56(3): 141-7.

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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