ZIP Kinase/DAPK3 Proteins, Antibodies, cDNA Clones Research Reagents

All ZIP Kinase/DAPK3 reagents are produced in house and quality controlled, including 2 ZIP Kinase/DAPK3 Antibody, 15 ZIP Kinase/DAPK3 Gene, 1 ZIP Kinase/DAPK3 Lysate, 1 ZIP Kinase/DAPK3 Protein, 1 ZIP Kinase/DAPK3 qPCR. All ZIP Kinase/DAPK3 reagents are ready to use.

ZIP Kinase/DAPK3 Protein (1)

    ZIP Kinase/DAPK3 Antibody (2)

      ZIP Kinase/DAPK3 cDNA Clone (15)

      ZIP Kinase/DAPK3 qPCR Primer (1)

      ZIP Kinase/DAPK3 Lysate (1)

        ZIP Kinase/DAPK3 Background

        Death-associated protein kinase 3, also known as DAP kinase 3, ZIP-kinase, DAPK3 and ZIPK, is a nucleus and cytoplasm protein which belongs to theprotein kinase superfamily, CAMK Ser/Thr protein kinase family and DAP kinase subfamily. DAPK3 / ZIPK contains oneprotein kinase domain. It is a serine/threonine kinase which acts as a positive regulator of apoptosis. It phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis. DAPK3 / ZIPK is a homodimer or forms heterodimers with ATF4. Both interactions require an intact leucine zipper domain and oligomerization is required for full enzymatic activity. It also binds to DAXX and PAWR, possibly in a ternary complex which plays a role in caspase activation. DAPK3 / ZIPK regulates myosin light chain phosphatase through phosphorylation of MYPT1 thereby regulating the assembly of the actin cytoskeleton, cell migration, invasiveness of tumor cells, smooth muscle contraction and neurite outgrowth. It is involved in the formation of promyelocytic leukemia protein nuclear body (PML-NB), one of many subnuclear domains in the eukaryotic cell nucleus, and which is involved in oncogenesis and viral infection.

        ZIP Kinase/DAPK3 References

        • Kawai T., et al., 1998, Mol. Cell. Biol. 18:1642-1651.
        • Murata-Hori M., et al., 1999, FEBS Lett. 451:81-84.
        • Kawai T., et al., 2003, Mol. Cell. Biol. 23:6174-6186.
        • Greenman C., et al., 2007, Nature 446:153-158.
        • Ohbayashi N., et al., 2008, Biochem. Biophys. Res. Commun. 372: 708 -712.

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