YES1 Proteins, Antibodies, cDNA Clones Research Reagents

YES1 (YES Proto-Oncogene 1, Src Family Tyrosine Kinase) is a protein coding gene located on human chromosome 18p11.32. YES1 is also known as Yes, c-yes, HsT441 and P61-YES. The human YES1 gene encodes a 60801 Da protein containing 543 amino acids. The YES1 protein is ubiquitously expressed in placenta, fat and other tissues. Among its related pathways are Interleukin-11 Signaling Pathway and Signaling by GPCR. YES1 is related to transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. SRC is an important paralog of YES1 gene. YES1 is associated with some diseases, including Sarcoma and Megaesophagus.

YES1 Protein (1)

    YES1 Antibody (2)

      YES1 cDNA Clone (13)


      YES1 Lysate (1)

        YES1 Background

        Proto-oncogene tyrosine-protein kinase Yes, also known as Proto-oncogene c-Yes, p61-Yes and YES1, is a cytoplasm protein that belongs to the protein kinase superfamily, Tyr protein kinase family and SRC subfamily. YES1 / c-Yes contains one protein kinase domain, one SH2 domain and one SH3 domain. It is thought that the subcellular distribution of Src-family tyrosine kinases, including c-Yes binding to the cellular membrane, is membranous and/or cytoplasmic. YES1 / c-Yes protein tyrosine kinase is known to be related to malignant transformation. YES1 / c-Yes and c-Src are the two most closely related members of the Src family of nonreceptor tyrosine kinases. Although there is much evidence to support redundancy in signaling between these two kinases. YES1 / c-Yes promotes the formation of the tight junction by phosphorylating occludin, while c-Src signaling downregulates occludin formation in a Raf-1 dependent manner. YES1 / c-Yes has tyrosine kinase activity. It promotes infectivity of Neisseria gonorrhoeae in epithelial cells by phosphorylating MCP / CD46.

        YES1 References

        • Summy,J.M. et al., 2003, Front Biosci  8 :s185-205.
        • Clump,D.A. et al., 2005, Growth Factors  23 (4):263-72.
        • Nonomura,T. et al., 2007,Int J Oncol  30 (1):105-11.

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