WT1 cDNA Clones Research Reagents

WT1 (WT1 Transcription Factor) is a protein coding gene located on human chromosome 11p13. WT1 is also known as GUD, AWT1, WAGR, WT33, NPHS4 and WIT-2. The human WT1 gene encodes a 49188 Da protein containing 449 amino acids. The WT1 protein is biasedly expressed in endometrium, testis and other tissues. Among its related pathways are Transcriptional misregulation in cancer and Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers. WT1 is related to nucleic acid binding and sequence-specific DNA binding. EGR2 is an important paralog of WT1 gene. WT1 is associated with some diseases, including Wilms Tumor 1 and Denys-Drash Syndrome.

WT1 cDNA Clone (16)

BC032861
NP_077742.3

In expression vector

WT1 qPCR Primer (1)

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WT1 Background

WT1 gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG.

WT1 References

  • Niavarani A, Herold T, Reyal Y, et al. A 4‐gene expression score associated with high levels of Wilms Tumor‐1 (WT1) expression is an adverse prognostic factor in acute myeloid leukaemia. British Journal of Haematology. 2016;172(3):401-411.

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