VSIG4 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

VSIG4 (V-Set And Immunoglobulin Domain Containing 4) is a protein coding gene located on human chromosome Xq12. VSIG4 is also known as CRIg and Z39IG. The human VSIG4 gene encodes a 43987 Da protein containing 399 amino acids. The VSIG4 protein is broadly expressed in placenta, lung and other tissues. Among its related pathways are Complement and coagulation cascades. VSIG4 is associated with some diseases, including T-Cell/Histiocyte Rich Large B Cell Lymphoma and Complement Component 3 Deficiency.

VSIG4 Protein (5)

    VSIG4 Antibody (11)

      VSIG4 ELISA Kit & Match Antibody ELISA Pair Set (2)

      VSIG4 cDNA Clone (26)


      VSIG4 Lysate (4)

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        VSIG4 Background

        VSIG4 (V-set and immunoglobulin domain containing 4), also known as complement receptor of the immunoglobulin superfamily (CRIg) and Z39Ig, is a type I transmembrane glycoprotein. It is a B7 family-related protein and an Ig superfamily member. In contrast to the B7 family members which contain two IgG domains, VSIG4 contains one complete V-type I g domain and a truncated C-type I g domain. VSIG4 is exclusively expressed on tissue resident macrophages and binds to multimers of C3b and iC3b that are covalently attached to particle surfaces. No VSIG4 expression appears to be present in T and B cells. VSIG4 functions as a negative regulator of T cell activation, and may be involved in the maintenance of peripheral T cell tolerance, and is also identified as a potent suppressor of established inflammation. Mouse VSIG4 is synthesized as a 28 amino acid precursor that contains a signal sequence, a V-type I g domain (aa 36-115), one potential N-linked glycosylation site, and a single transmembrane domain. The V-type I g domain of mouse VSIG4 shares 86% and 8% aa sequence identity with the V-type I g domains of rat and human VSIG4, respectively.

        VSIG4 References

        • Vogt, L. et al., 2006, J Clin Invest.116: 2817-2826.
        • Helmy, K. et al., 2006, Cell. 124:915-927.
        • Wiesmann, C. et al., 2006, Nature. 444:217-220.
        • Zang,X. et al., 2006, J Clin Invest. 116: 2590-2593.
        • Katschke, KJ. et al., 2007, J. Exp. Med. 204:1319-1325.
        • He,JQ. et al., 2008, Mol Immunol. 45: 4041-4047.

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