VEGF C Proteins, Antibodies, cDNA Clones Research Reagents

VEGFC (Vascular Endothelial Growth Factor C) is a protein coding gene located on human chromosome 4q34.3. VEGFC is also known as VRP, Flt4-L, LMPH1D and LMPHM4. The human VEGFC gene encodes a 46883 Da protein containing 419 amino acids. The VEGFC protein is broadly expressed in thyroid, placenta and other tissues. Among its related pathways are HIF1Alpha Pathway and Signaling by GPCR. VEGFC is related to growth factor activity and vascular endothelial growth factor receptor 3 binding. VEGFD is an important paralog of VEGFC gene. VEGFC is associated with some diseases, including Lymphatic Malformation 4 and Hereditary Lymphedema Id.

VEGF C Protein (3)

    VEGF C Antibody (2)

      VEGF C cDNA Clone (39)

      NM_005429.2
      NM_009506.2
      NM_053653.1

      VEGF C Lysate (4)

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        VEGF C Background

        Vascular endothelial growth factor C (VEGF-C) is a member of the VEGF family. Upon biosynthesis, VEGF-C protein is secreted as a non-covalent momodimer in an anti-parellel fashion. VEGF-C protein is a dimeric glycoprotein, as a ligand for two receptors, VEGFR-3 (Flt4), and VEGFR-2. VEGF-C may function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis. VEGF-C protein is over-expressed in various human cancers including breast cancer and prostate cancer. VEGF-C/VEGFR-3 axis, through different signaling pathways, plays a critical role in cancer progression by regulating different cellular functions, such as invasion, proliferation, and resistance to chemotherapy. Thus, targeting the VEGF-C/VEGFR-3 axis may be therapeutically significant for certain types of tumors.

        VEGF C References

        • Joukov V, et al. (1997) Vascular endothelial growth factors VEGF-B and VEGF-C. J Cell Physiol. 173(2): 211-5.
        • Su JL, et al. (2007) The role of the VEGF-C/VEGFR-3 axis in cancer progression. Br J Cancer. 96(4): 541-5.
        • Anisimov A, et al. (2009) Activated forms of VEGF-C and VEGF-D provide improved vascular function in skeletal muscle. Circ Res. 104(11): 1302-12.

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