VE-Cadherin Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All VE-Cadherin reagents are produced in house and quality controlled, including 26 VE-Cadherin Antibody, 1 VE-Cadherin ELISA, 39 VE-Cadherin Gene, 4 VE-Cadherin Lysate, 4 VE-Cadherin Protein, 3 VE-Cadherin qPCR. All VE-Cadherin reagents are ready to use.

VE-Cadherin Protein (4)

    VE-Cadherin Antibody (26)

      VE-Cadherin ELISA Kit & Match Antibody ELISA Pair Set (1)

      VE-Cadherin cDNA Clone (39)

      NM_001795.3
      NM_009868.4
      NM_001107407.1

      VE-Cadherin Lysate (4)

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        VE-Cadherin Background

        Cadherins (Calcium dependent adhesion molecules) are a class of transmembrane proteins. Cadherin-5, also known as VE-cadherin, CDH5 and CD144, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the formation, maturation and remodeling of the vascular wall. VE-Cadherin is widely considered to be specific for vascular endothelia in which it is either the sole or the predominant cadherin, often co-existing with N-cadherin. This specificity of VE-cadherin for vascular endothelial cells is important not only in blood and lymph vessel biology and medicine, but also for cell-type-based diagnoses, notably those of metastatic tumors. As a classical cadherin, VE-Cadherin links endothelial cells together by homophilic interactions mediated by its extracellular part and associates intracellularly with the actin cytoskeleton via catenins. Mechanisms that regulate VE-cadherin-mediated adhesion are important for the control of vascular permeability and leukocyte extravasation. In addition to its adhesive functions, VE-Cadherin regulates various cellular processes such as cell proliferation and apoptosis and modulates vascular endothelial growth factor receptor functions. Consequently, VE-cadherin is essential during embryonic angiogenesis.

        VE-Cadherin References

        • Taveau JC, et al. (2008) Structure of artificial and natural VE-cadherin-based adherens junctions. Biochem Soc Trans. 36(Pt 2): 189-93.
        • Vestweber D. (2008) VE-cadherin: the major endothelial adhesion molecule controlling cellular junctions and blood vessel formation. Arterioscler Thromb Vasc Biol. 28(2): 223-32.
        • Gavard J. (2009) Breaking the VE-cadherin bonds. FEBS Lett. 583(1): 1-6.
        • Vestweber D, et al. (2009) Cell adhesion dynamics at endothelial junctions: VE-cadherin as a major player. Trends Cell Biol. 19(1): 8-15.
        • Boda-Heggemann J, et al. (2009) Beyond vessels: occurrence and regional clustering of vascular endothelial (VE-)cadherin-containing junctions in non-endothelial cells. Cell Tissue Res. 335(1): 49-65.

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