UCN2 Antibodies, cDNA Clones Research Reagents

UCN2 (Urocortin 2, also known as UR; SRP; URP; UCNI; UCN-II), located on 3p21.31, is a Protein Coding gene. The gene produces a 12146 Da protein composed of 112 amino acids. The human SRP open reading frame contains a signal peptide for secretion, and the region containing the 43-amino acid mature peptide is flanked by potential proteolytic cleavage sites and an alpha-amidation donor residue. UCN2 and its receptor CRHR2 are highly expressed in skeletal muscle and play a role in regulating energy balance and glucose metabolism.

UCN2 Antibody (1)

    UCN2 cDNA Clone (13)

    BC002647

    UCN2 qPCR Primer (1)

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    UCN2 Background

    The neuropeptide urocortin 2 (UCN2) and its receptor corticotropin-releasing hormone receptor 2 (CRHR2) are highly expressed in skeletal muscle and play a role in regulating energy balance and glucose metabolism. UCN2 is a 38-amino acid peptide of the corticotropin-releasing factor family. Intravenous (IV) delivery of an adeno-associated virus vector serotype 8 encoding Ucn2 (AAV8.Ucn2) increases insulin sensitivity and glucose disposal in mice with insulin resistance. Modified UCN2 peptides may be efficacious in the treatment of type 2 diabetes by acting as an insulin sensitizer in skeletal muscle. UCN2 - corticotropin-releasing hormone receptor 2 signaling has favorable effects in the cardiovascular system, including vasodilation, lowering of blood pressure and systemic peripheral resistance, increase in cardiac output and cardiac contractility, as well as cardioprotection against ischemia-reperfusion injury.

    UCN2 References

    • Walczewska J, et al. (2019) Urocortin 2 in patients with hypertension treated with angiotensin converting enzyme inhibitors or angiotensin receptor blockers. J Physiol Pharmacol 70 (2).
    • Rademaker MT, et al. (2009) Urocortin 2 inhibits furosemide-induced activation of renin and enhances renal function and diuretic responsiveness in experimental heart failure. Circ Heart Fail 2 (6): 532-540.
    • Kim YC, et al. (2019) Significant alteration of liver metabolites by aav8.Urocortin 2 gene transfer in mice with insulin resistance. PLoS One 14 (12): e0224428.
    • Borg ML, et al. (2019) Modified ucn2 peptide acts as an insulin sensitizer in skeletal muscle of obese mice. Diabetes 68 (7): 1403-1414.

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