TWEAK/TNFSF12 Proteins, cDNA Clones Research Reagents

All TWEAK/TNFSF12 reagents are produced in house and quality controlled, including 65 TWEAK/TNFSF12 Gene, 4 TWEAK/TNFSF12 Lysate, 4 TWEAK/TNFSF12 Protein, 3 TWEAK/TNFSF12 qPCR. All TWEAK/TNFSF12 reagents are ready to use.

TWEAK/TNFSF12 Protein (4)

    TWEAK/TNFSF12 cDNA Clone (65)


    TWEAK/TNFSF12 Lysate (4)

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      TWEAK/TNFSF12 Background

      TNFSF12 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is a ligand for the FN14/TWEAKR receptor. TNFSF12 has overlapping signaling functions with TNF, but displays a much wider tissue distribution. It can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. It is also found that TNFSF12 promotes proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. TNFSF12 also is a weak inducer of apoptosis in some cell types and mediates NF-kappa-B activation.

      TWEAK/TNFSF12 References

      • Wiley SR, et al. (2004) TWEAK, a member of the TNF superfamily, is a multifunctional cytokine that binds the TweakR/Fn14 receptor. Cytokine Growth Factor Rev. 14(3-4):241-9.
      • Campbell S, et al. (2006) The role of TWEAK/Fn14 in the pathogenesis of inflammation and systemic autoimmunity. Front Biosci. 9:2273-84.
      • Lynch CN, et al. (1999) TWEAK induces angiogenesis and proliferation of endothelial cells. J Biol Chem. 274(13):8455-9.

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