TSC22D1 Proteins, Antibodies, cDNA Clones Research Reagents

TSC22D1 (TSC22 Domain Family Member 1) is a protein coding gene located on human chromosome 13q14.11. TSC22D1 is also known as Ptg-2, TSC22 and TGFB1I4. The human TSC22D1 gene encodes a 109677 Da protein containing 1073 amino acids. The TSC22D1 protein is ubiquitously expressed in prostate, endometrium and other tissues. Among its related pathways are Development_TGF-beta receptor signaling and Ectoderm Differentiation. TSC22D1 is related to DNA-binding transcription factor activity. TSC22D2 is an important paralog of TSC22D1 gene. TSC22D1 is associated with some diseases, including Brain Sarcoma and Salivary Gland Carcinoma.

TSC22D1 Protein (2)

    TSC22D1 Antibody (10)

      TSC22D1 cDNA Clone (45)

      TSC22D1 Background

      TSC22 domain family, member 1 (TSC22D1) is one of the TGF-beta-stimulated clone-22 (TSC-22). TSC-22 was reported to be a differentiation-inducing factor that negatively regulates the growth of salivary gland cancer cells. TSC22D1, which encodes transforming growth factor beta-stimulated clone 22 (TSC-22), is thought to be a tumor suppressor because its expression is lost in many glioblastoma, salivary gland, and prostate cancers. TSC-22 is the founding member of the TSC-22/DIP/Bun family of leucine zipper transcription factors. TSC-22 may play an important role in maintaining the differentiated phenotype in salivary gland tumors, and may be a possible target of leukemia therapy. TSC22D1 forms homodimers via its conserved leucine zipper domain and heterodimerizes with TSC22D4. TSC22D1 has transcriptional repressor activity.

      TSC22D1 References

      • Doi Y, et al. (2008) Expression and cellular localization of TSC-22 in normal salivary glands and salivary gland tumors: implications for tumor cell differentiation. Oncol Rep. 19(3): 609-16.
      • Wu X, et al. (2008) The Drosophila homolog of human tumor suppressor TSC-22 promotes cellular growth, proliferation, and survival. Proc Natl Acad Sci U S A. 105(14): 5414-9.
      • Lu Y, et al. (2007) Identification of TSC-22 as a potential tumor suppressor that is upregulated by Flt3-D835V but not Flt3-ITD. Leukemia. 21(11): 2246-57.

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