Troponin C Proteins, Antibodies, cDNA Clones Research Reagents

TNNC1 (Troponin C1, Slow Skeletal And Cardiac Type) is a protein coding gene located on human chromosome 3p21.1. TNNC1 is also known as TNC, TN-C, TNNC, CMD1Z, and CMH13. The human TNNC1 gene encodes a 18403 Da protein containing 161 amino acids. The TNNC1 protein is restrictedly expressed toward heart. Among its related pathways are Dilated cardiomyopathy (DCM) and Cardiac muscle contraction. TNNC1 is related to calcium ion binding and actin filament binding. TNNC2 is an important paralog of TNNC1 gene. TNNC1 is associated with some diseases, including Cardiomyopathy, Familial Hypertrophic, 13 and Cardiomyopathy, Dilated, 1Z.

Troponin C Protein (1)

    Troponin C Antibody (5)

      Troponin C cDNA Clone (30)

      Troponin C qPCR Primer (1)

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      Troponin C Background

      Troponin I, also known as TNNC1, is part of the troponin complex. This complex contains 3 subunits: troponin I (TnI), troponin T (TnT) and troponin C (TnC). Troponin I is the inhibitory subunit, blocking actin-myosin interactions and thereby mediating striated muscle relaxation. It binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place. Because of it myosin cannot bind actin in relaxed muscle. When calcium binds to the Troponin C it causes conformational changes which lead to dislocation of troponin I and finally tropomyosin leaves the binding site for myosin on actin leading to contraction of muscle.

      Troponin C References

      • Kalaji FR. et al., 2012, Saudi J Kidney Dis Transpl. 23 (5): 939-45.
      • Wijnker PJ. et al., 2013, Am J Physiol Heart Circ Physiol. 304 (2): H260-8.
      • Solaro RJ. et al., 2013, Circ Res. 112 (2): 355-66.

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