TrkB Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All TrkB reagents are produced in house and quality controlled, including 5 TrkB Antibody, 1 TrkB ELISA, 53 TrkB Gene, 8 TrkB Lysate, 8 TrkB Protein, 3 TrkB qPCR. All TrkB reagents are ready to use.

TrkB Protein (8)

    TrkB Antibody (5)

      TrkB ELISA Kit & Match Antibody ELISA Pair Set (1)

      TrkB cDNA Clone (53)

      NM_001007097.1
      NM_001018064.2

      In expression vector

      NM_001025074.1
      NM_001163168.1
      XM_003432718.1

      TrkB Lysate (8)

        TrkB Background

        TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptors with intracellular tyrosine kinase activity. TrkB/NTRK2 is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. TrkB tyrosine kinase (TrkB) or NTRK2 is coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3-K and PLCgamma signaling pathways. There are four members of the Trk family; TrkA, TrkB and TrkC and a related p75NTR receptor. Each family member binds different neurotrophins with varying affinities. TrkB/NTRK has highest affinity for brain-derived neurotrophic factor (BDNF) and is involved in neuronal plasticity, longterm potentiation and apoptosis of CNS neurons. Other neurotrophins include nerve growth factor(NGF), neurotrophin-3 and neurotrophin-4. TrkB/NTRK is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in TrkB/NTRK have been associated with obesity and mood disorders.

        TrkB References

        • Klein R, et al. (1990) The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain. Cell. 61 (4): 647-56.
        • Rose CR, et al. (2003) Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glia cells. Nature. 426 (6962): 74-8.
        • Yamada K, et al. (2004) Brain-derived neurotrophic factor/TrkB signaling in memory processes. J Pharmacol Sci. 91 (4): 267-70.

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