TRH Antibodies, cDNA Clones Research Reagents

TRH (Thyrotropin Releasing Hormone, also known as TRF; Pro-TRH), located on 3q22.1, is a Protein Coding gene. The gene produces a 27404 Da protein composed of 242 amino acids. TRH is a tripeptide (Glu-his-pro-NH2) hormone. The major recognized function of TRH is the maintenance of thyroid hormone homeostasis via regulation of thyroid-stimulating hormone (TSH) secretion. TRH also regulates the release of other hormones, such as prolactin, growth hormone, vasopressin, and insulin. Diseases such as Thyrotropin-Releasing Hormone Deficiency and Hyperprolactinemia are associated with TRH.

TRH Antibody (1)

    TRH cDNA Clone (26)

    BC069375
    NM_009426.3

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    TRH Background

    Thyrotropin-releasing hormone (TRH) is the first hypothalamic hypophysiotropic neuropeptide whose sequence has been chemically characterized. The primary structure of TRH (pGlu-His-Pro-NH(2)) has been fully conserved across the vertebrate phylum. TRH is generated from a large precursor protein that contains multiple repeats of the TRH progenitor tetrapeptide Gln-His-Pro-Gly. In all tetrapods, TRH-expressing neurons located in the hypothalamus project towards the external zone of the median eminence. TRH has an important role in the regulation of energy homeostasis, feeding behavior, thermogenesis, and autonomic regulation. TRH causes a variety of thyroidal and non-thyroidal effects, the best known being the feedback regulation of thyroid hormone levels. TRH controls energy homeostasis mainly through its Hypophysiotropic Actions to regulate circulating thyroid hormone levels.

    TRH References

    • Singh O, et al. (2019) Thyrotropin-releasing hormone (trh) in the brain and pituitary of the teleost, clarias batrachus and its role in regulation of hypophysiotropic dopamine neurons. J Comp Neurol 527 (6): 1070-1101.
    • Shibusawa N, et al. (2008) Thyrotropin-releasing hormone (trh) in the cerebellum. Cerebellum 7 (1): 84-95.
    • Galas L, et al. (2009) Trh acts as a multifunctional hypophysiotropic factor in vertebrates. Gen Comp Endocrinol 164 (1): 40-50.
    • Fröhlich E, et al. (2019) The forgotten effects of thyrotropin-releasing hormone: Metabolic functions and medical applications. Front Neuroendocrinol 52 29-43.

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