TRAF3 Antibodies, cDNA Clones Research Reagents

TRAF3 (TNF Receptor Associated Factor 3) is a protein coding gene located on human chromosome 14q32.32. TRAF3 is also known as CAP1, LAP1, CAP-1, CRAF1, IIAE5, CD40bp and RNF118. The human TRAF3 gene encodes a 64490 Da protein containing 568 amino acids. The TRAF3 protein is ubiquitously expressed in lymph node, appendix and other tissues. Among its related pathways are Apoptosis Modulation and Signaling and NF-KappaB Family Pathway. TRAF3 is related to protein kinase binding and ubiquitin-protein transferase activity. TRAF5 is an important paralog of TRAF3 gene. TRAF3 is associated with some diseases, including Encephalopathy, Acute, Infection-Induced 5 and Herpes Simplex Encephalitis.

TRAF3 Antibody (1)

    TRAF3 cDNA Clone (1)


    In expression vector

    TRAF3 Background

    Tumor necrosis factor receptor-associated factor 3 (TRAF3) is a main regulator of antiviral and anti-inflammatory pathways in mammals, which is considered to induce type I interferon (IFN) activation and negatively regulate the activation of the canonical and non-canonical NF-kappaB pathways. Parkin plays a novel role in innate immune signaling by targeting TRAF3 for degradation, and maintaining the balance of innate antiviral immunity. Loss-of-function mutations in genes encoding the signaling protein tumor necrosis factor receptor-associated factor 3 (TRAF3) are commonly found in human B-cell malignancies, especially multiple myeloma and B-cell lymphoma (BCL). B-cell TRAF3 deficiency results in enhanced cell survival, elevated activation receptor signaling, and increased activity of certain transcriptional pathways regulating expression of prosurvival proteins. TNF receptor-associated factor 3 (TRAF3) is a highly versatile regulator of immune response. TRAF3 expression in macrophages could be a novel therapeutic target protein for the treatment of acute pancreatitis.

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