TRAF1 Antibodies, cDNA Clones Research Reagents

TRAF1 (TNF Receptor Associated Factor 1) is a protein coding gene located on human chromosome 9q33.2. TRAF1 is also known as EBI6 and MGC:10353. The human TRAF1 gene encodes a 46164 Da protein containing 416 amino acids. The TRAF1 protein is broadly expressed in lymph node, appendix and other tissues. Among its related pathways are Apoptosis Modulation and Signaling and Transcriptional misregulation in cancer. TRAF1 is related to ubiquitin protein ligase binding and thioesterase binding. TRAF2 is an important paralog of TRAF1 gene. TRAF1 is associated with some diseases, including Anaplastic Large Cell Lymphoma and Lymphoma, Hodgkin, Classic.

TRAF1 Antibody (1)

    TRAF1 cDNA Clone (15)

    TRAF1 qPCR Primer (1)

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    TRAF1 Background

    Tumor necrosis factor receptor (TNFR)-associated factor 1 (TRAF1) is a unique TRAF protein that can interact directly or indirectly with multiple TNFR family members, regulatory proteins, kinases, and adaptors that contribute to its diverse functions in specific tissues. Activation of the TRAF1/ASK1/JNK/NF-kappaB signaling pathway is involved in the inflammation of severe acute pancreatitis (SAP). Curcumin exerts anti-inflammatory effects by suppressing this proinflammatory pathway. Tumor necrosis factor receptor-associated factor 1 has potential direct/indirect regulations with the cancer stem cell markers in oral squamous cell carcinoma, which may help in further analysis of the cancer stem cell characteristics.

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