TIE2 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

TEK (TEK Receptor Tyrosine Kinase) is a protein coding gene located on human chromosome 9p21.2. TEK is also known as TIE2, VMCM, GLC3E, TIE-2, VMCM1 and CD202B. The human TEK gene encodes a 125830 Da protein containing 1124 amino acids. The TEK protein is broadly expressed in lung, placenta and other tissues. Among its related pathways are RET signaling and Signaling by GPCR. TEK is related to transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. TIE1 is an important paralog of TEK gene. TEK is associated with some diseases, including Venous Malformations, Multiple Cutaneous And Mucosal and Glaucoma 3, Primary Congenital, E.

TIE2 Protein (10)

TIE2 Antibody (12)

    TIE2 ELISA Kit & Match Antibody ELISA Pair Set (1)

    TIE2 cDNA Clone (39)


    TIE2 Lysate (9)

      TIE2 Background

      TEK, or TIE-2, is an endothelial cell-specific receptor tyrosine kinase (RTK) that is known as a functioning molecule of vascular endothelial cells. TEK comprises a subfamily of RTK with TIE, and these two receptors play critical roles in vascular maturation, maintenance of integrity and remodeling. Targeted mutagenesis of both Tek and its agonistic ligand, Angiopoietin-1, result in embryonic lethality, demonstrating that the signal transduction pathways mediated by this receptor are crucial for normal embryonic development. TEK signaling is indispensable for the development of the embryonic vasculature and suggests that TEK signaling may also be required for the development of the tumor vasculature.

      TIE2 References

      • Jones N, et al. (1998) The Tek / Tie2 receptor signals through a novel Dok-related docking protein, Dok-R. Oncogene. 17(9): 1097-108.
      • Sato A, et al. (1998) Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells. Int Immunol. 10(8): 1217-27.
      • Huang L, et al. (1995) GRB2 and SH-PTP2: potentially important endothelial signaling molecules downstream of the TEK / TIE2 receptor tyrosine kinase. Oncogene. 11(10): 2097-103.

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