Transferrin Receptor/TFRC Proteins, Antibodies, cDNA Clones Research Reagents

TFRC (Transferrin Receptor) is a protein coding gene located on human chromosome 3q29. TFRC is also known as T9, TR, TFR, p90, CD71, TFR1, TRFR and IMD46. The human TFRC gene encodes an 84871 Da protein containing 760 amino acids. The TFRC protein is broadly expressed in bone marrow, placenta and other tissues. Among its related pathways are Clathrin-mediated endocytosis and Clathrin derived vesicle budding. TFRC is related to double-stranded RNA binding. TFR2 is an important paralog of TFRC gene. TFRC is associated with some diseases, including Immunodeficiency 46 and Iron Deficiency Anemia.

All Transferrin Receptor/TFRC Reagents

Transferrin Receptor/TFRC Protein (6)

Transferrin Receptor/TFRC Antibody (27)

    Transferrin Receptor/TFRC cDNA Clone (54)


    Transferrin Receptor/TFRC Lysate (5)

      Transferrin Receptor/TFRC Background

      Transferrin receptor protein 1, also known as transferrin receptor, Trfr, p9, CD71 and TFRC, is a single-pass type II membrane protein that belongs to the peptidase M28 family and M28B subfamily. TFRC / CD71 is a membrane-bound protein expressed in larger amounts in proliferating. The specific expression of TFRC can represent a diagnostic tool or a therapeutic target in solid tumours expressing this antigen. Transferrin receptor is necessary for development of erythrocytes and the nervous system. TFRC / CD71 is regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation. TFRC / CD71 represents a marker of malignant transformation in the pancreas that could be applied as potential diagnostic and therapeutic target.

      Transferrin Receptor/TFRC References

      • Douabin-Gicquel V., et al., 2001,Hum. Genet. 109:393-401.
      • Ryschich,E. et al., 2004,Eur J Cancer. 40 (9):1418-22.
      • Tosoni D., et al., 2005, Cell 123:875-888.
      • Wollscheid B., et al., 2009, Nat. Biotechnol. 27:378-386.

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