TCTP/TPT1 Proteins, Antibodies, cDNA Clones Research Reagents

TPT1 (Tumor Protein, Translationally-Controlled 1) is a protein coding gene located on human chromosome 13q14.13. TPT1 is also known as HRF, p02, p23 and TCTP. The human TPT1 gene encodes a 19595 Da protein containing 172 amino acids. The TPT1 protein is ubiquitously expressed in ovary, thyroid and other tissues. Among its related pathways are Ca, cAMP and Lipid Signaling and Cytoskeletal Signaling. TPT1 is related to transcription factor binding. TPT1 is associated with some diseases, including Urticaria and Drug Allergy.

TCTP/TPT1 Protein (1)

    TCTP/TPT1 Antibody (2)

      TCTP/TPT1 cDNA Clone (30)

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      TCTP/TPT1 Background

      Tumor protein, also known as TPT1, is a highly conserved protein among many eukaryotic organisms. Tumor protein is involved in a variety of cellular activities, including microtubule stabilization, calcium-binding activities, and apoptosis. The Mammalian translationally controlled tumour protein (TPT1) (or P23) is a protein that has been found to be preferentially synthesised in cells during the early growth phase of some types of tumour, but which is also expressed in normal cells. It was first identified as a histamine-releasing factor, acting in IgE +-dependent allergic reactions. In addition, TPT1 has been shown to bind to tubulin in the cytoskeleton, has a high affinity for calcium, is the binding target for the antimalarial compound artemisinin, and is induced in vitamin D-dependent apoptosis. TPT1 production is thought to be controlled at the translational as well as the transcriptional level.

      TCTP/TPT1 References

      • Thaw P. et al., 2001, Nat Struct Biol. 8 (8): 701-4.
      • Thiele H. et al., 2000, Eur J Biochem. 267 (17): 5473-81.
      • Chitpatima ST. et al., 1988, Nucleic Acids Res. 16 (5): 2350.

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