TACI Proteins, Antibodies, cDNA Clones Research Reagents

TNFRSF13B (TNF Receptor Superfamily Member 13B) is a protein coding gene located on human chromosome 17p11.2. TNFRSF13B is also known as CVID, RYZN, TACI, CD267, CVID2, IGAD2 and TNFRSF14B. The human TNFRSF13B gene encodes a 31816 Da protein containing 293 amino acids. The TNFRSF13B protein is biasedly expressed in spleen, lymph node and other tissues. Among its related pathways are TRAF Pathway and TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions. TNFRSF13B is associated with some diseases, including Immunodeficiency, Common Variable, 2 and Immunoglobulin A Deficiency 2.

TACI Protein (3)

    TACI Antibody (5)

      TACI cDNA Clone (31)


      In expression vector

      In lentiviral vector


      TACI Lysate (2)

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        TACI Background

        Tumor necrosis factor receptor superfamily, member 13B (TNFRSF13B) also known as Transmembrane activator and CAML interactor (TACI) and CD267 antigen, is a member of the tumor necrosis factor receptor superfamily. TNFRSF13B is a trimeric cytokine receptor that binds tumor necrosis factors (TNF). The receptor cooperates with an adaptor protein which is important in determining the outcome of the response. Members of the TNF receptor superfamily (TNFRSF) have crucial roles in both innate and adaptive immunity and in cellular apoptosis process. Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal's survival. Certain cells have unique sensors, termed death receptors or tumour necrosis factor (TNFR), on their surface. Tumour necrosis factors (TNFR) detect the presence of extracellular death signals and, in response, they rapidly ignite the cell's intrinsic apoptosis machinery. TACI/TNFRSF13B/CD267 induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand.

        TACI References

        • Salzer U, et al. (2005) Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans. Nat Genet. 37(8): 820-8.
        • Salzer U, et al. (2009) Relevance of biallelic versus monoallelic TNFRSF13B mutations in distinguishing disease-causing from risk-increasing TNFRSF13B variants in antibody deficiency syndromes. Blood. 113(9): 1967-76.
        • Mohammadi J, et al. (2009) Novel mutations in TACI (TNFRSF13B) causing common variable immunodeficiency. J Clin Immunol. 29(6): 777-85.

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