SWAP70 Antibodies, cDNA Clones Research Reagents

SWAP70 (Switching B Cell Complex Subunit SWAP70, also known as HSPC321; SWAP-70), located on 11p15.4, is a Protein Coding gene. The gene produces a 68998 Da protein composed of 585 amino acids. SWAP70 is a different type of Rac-GEF which, independently of Ras, transduces signals from tyrosine kinase receptors to Rac. SWAP70 functions as a guanine nucleotide exchange factor for Rac and RhoA regulating F-actin cytoskeletal rearrangements and playing a crucial role in mammalian cell activation, migration, adhesion, and invasion.

SWAP70 Antibody (1)

    SWAP70 cDNA Clone (15)

    SWAP70 qPCR Primer (1)

    SWAP70 Background

    SWAP70 functions as a guanine nucleotide exchange factor for Rac and RhoA regulating F-actin cytoskeletal rearrangements and playing a crucial role in mammalian cell activation, migration, adhesion, and invasion. Rearrangements of the actin cytoskeleton are regulated in part by dynamic localized activation and inactivation of Rho family small GTPases. SWAP70 binds to and activates the small GTPase RAC1 as well as binding to filamentous actin and PIP3. SWAP70 adopts a distinct conformation at the plasma membrane, which in migrating glioma cells is enriched at the leading edge but does not always associate with its PIP3 -dependent translocation to the membrane. NRL1 interacts in yeast and in planta with a guanine nucleotide exchange factor called SWAP70. SWAP70 associates with endosomes and is a positive regulator of immunity.

    SWAP70 References

    • Xu X, et al. (2014) Swap70b is required for convergent and extension cell movement during zebrafish gastrulation linking wnt11 signalling and rhoa effector function. Dev Biol 386 (1): 191-203.
    • Kriplani N, et al. (2019) Swap70 undergoes dynamic conformational regulation at the leading edge of migrating cells. FEBS Lett 593 (4): 395-405.
    • He Q, et al. (2018) Plant pathogen effector utilizes host susceptibility factor nrl1 to degrade the immune regulator swap70. Proc Natl Acad Sci U S A 115 (33): E7834-e7843.

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