SUV39H1 Antibodies, cDNA Clones Research Reagents

SUV39H1 (Suppressor Of Variegation 3-9 Homolog 1) is a protein coding gene located on human chromosome Xp11.23. SUV39H1 is also known as MG44, KMT1A, SUV39H and H3-K9-HMTase 1. The human SUV39H1 gene encodes a 47907 Da protein containing 412 amino acids. The SUV39H1 protein is ubiquitously expressed in bone marrow, lymph node and other tissues. Among its related pathways are Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway and Lysine degradation. SUV39H1 is related to chromatin binding and transcription regulatory region sequence-specific DNA binding. SUV39H2 is an important paralog of SUV39H1 gene. SUV39H1 is associated with some diseases, including Hyperoxaluria, Primary, Type I and Retinoblastoma.

SUV39H1 Antibody (1)

    SUV39H1 cDNA Clone (31)


    In cloning vector

    SUV39H1 qPCR Primer (1)

    SUV39H1 Background

    SUV39H1, the histone methyltransferase (HMTase) of histone H3 lysine 9 trimethylation (H3K9me3), is a known transcriptional repressor of inflammatory genes. SUV39H1 as an oncogene in melanoma and underscore the role of chromatin factors in regulating tumorigenesis. The ability of mycobacteria to form biofilms, a survival strategy of the bacteria dependent upon cell-cell adhesion, was dramatically reduced in the presence of SUV39H1. Thus, this novel defense mechanism against mycobacteria represents a surrogate function of the epigenetic modulator, SUV39H1, and operates by interfering with their cell-cell adhesion ability. Overexpression of SUV39H1 may reduce renal inflammation and apoptosis via epigenetic modulation, thus plays a protective role in DN.

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