STUB1 Antibodies, cDNA Clones Research Reagents

STUB1 (STIP1 Homology And U-Box Containing Protein 1, also known as CHIP; SCA48; UBOX1; SCAR16; HSPABP2; NY-CO-7; SDCCAG7), located on 16p13.3, is a Protein Coding gene. The gene produces a 34856 Da protein composed of 303 amino acids. STUB1 is a ubiquitin ligase/cochaperone that participates in protein quality control by targeting a broad range of chaperone protein substrates for degradation. Human CHIP shares 97% and 53% amino acid identity with its mouse and Drosophila homologs, respectively, with the highest conservation in the 94 residues of the C terminus.

STUB1 Antibody (5)

    STUB1 cDNA Clone (26)

    NM_001293197.1

    In cloning vector

    NM_005861.2

    In lentiviral vector

    NM_001025625.2

    In cloning vector

    In lentiviral vector

    STUB1 qPCR Primer (1)

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    STUB1 Background

    CHIP, the protein encoded by STUB1, is a central component of cellular protein homeostasis and interacts with several key proteins involved in the pathogenesis of manifold neurodegenerative diseases. Missense and truncating mutations in STUB1 lead to SCAR16. CHIP/STUB1 ubiquitin ligase is a negative co-chaperone for HSP90/HSC70, and its expression is reduced or lost in several cancers, including breast cancer. Pathogenic variants in STUB1 were initially described in autosomal recessive spinocerebellar ataxia type 16 and dominant cerebellar ataxia with cerebellar cognitive dysfunction (SCA48). Data indicated that STUB1 deficiency leads both to the intracellular accumulation of protein aggregates and to an increase in the secretion of small extracellular vesicles (sEVs), including exosomes. Secreted sEVs are enriched in ubiquitinated and/or undegraded proteins and protein oligomers.

    STUB1 References

    • Roux T, et al. (2020) Clinical, neuropathological, and genetic characterization of stub1 variants in cerebellar ataxias: A frequent cause of predominant cognitive impairment. Genet Med 22 (11): 1851-1862.
    • Luan H, et al. (2018) Loss of the nuclear pool of ubiquitin ligase chip/stub1 in breast cancer unleashes the mzf1-cathepsin pro-oncogenic program. Cancer Res 78 (10): 2524-2535.
    • Hayer SN, et al. (2017) Stub1/chip mutations cause gordon holmes syndrome as part of a widespread multisystemic neurodegeneration: Evidence from four novel mutations. Orphanet J Rare Dis 12 (1): 31.
    • Ferreira JV, et al. (2019) Exosomes and stub1/chip cooperate to maintain intracellular proteostasis. PLoS One 14 (10): e0223790.

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