STK40 Proteins, cDNA Clones Research Reagents

STK40 (Serine/Threonine Kinase 40) is a protein coding gene located on human chromosome 1p34.3. STK40 is also known as SHIK and SgK495. The human STK40 gene encodes a 49001 Da protein containing 435 amino acids. The STK40 protein is ubiquitously expressed in testis, ovary and other tissues. Among its related pathways is Sweet Taste Signaling. STK40 is related to transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. TRIB3 is an important paralog of STK40 gene. STK40 is associated with some diseases, such as Hypomelanosis Of Ito.

STK40 Protein (1)

    STK40 cDNA Clone (15)

    STK40 qPCR Primer (1)

    STK40 Lysate (1)

      STK40 Background

      STK40 is localized to both the cytoplasm and the nucleus. It is ubiquitously expressed. Mechanistically, Stk40 interacts with Rcn2, which also activates Erk1/2 to induce ExEn specification in mouse ESCs. Stk40 is able to activate the Erk/MAPK pathway and induce extraembryonic-endoderm (ExEn) differentiation in mouse ESCs. Interestingly, cells overexpressing Stk40 exclusively contribute to the ExEn layer of chimeric embryos when injected into host blastocysts. In contrast, deletion of Stk40 in ESCs markedly reduces ExEn differentiation in vitro. STK40 has a central serine/threonine protein kinase domain and is homologous to TRB-3, a protein that regulates activation of MAP kinases and inhibits NFκB-mediated gene transcription. Similarly, overexpression of STK40 inhibits NFκB activation triggered by TNF and also inhibits p53-mediated transcription. There are four named isoforms of STK40 that are produced as a result of alternative splicing.

      STK40 References

      • Strausberg RL, et al. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci. 99(26):16899-903.
      • Wiemann S, et al. (2001) Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. Genome Res. 11(3):422-35.
      • Hartley JL, et al. (2001) DNA cloning using in vitro site-specific recombination. Genome Res. 10(11): 1788-95.

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