STIM1 Proteins, Antibodies, cDNA Clones Research Reagents

All STIM1 reagents are produced in house and quality controlled, including 2 STIM1 Antibody, 26 STIM1 Gene, 1 STIM1 IP Kit, 1 STIM1 Lysate, 1 STIM1 Protein, 2 STIM1 qPCR. All STIM1 reagents are ready to use.

STIM1 Protein (1)

    STIM1 Antibody (2)

      STIM1 cDNA Clone (26)

      NM_003156.3
      NM_009287.4

      STIM1 Lysate (1)

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        STIM1 Background

        Stromal interaction molecule 1, also known as STIM1 and GOK, is a cell membrane, a single-pass type I membrane protein and a endoplasmic reticulum membrane protein. STIM1 / GOK is ubiquitously expressed in various human primary cells and tumor cell lines. It contains oneEF-hand domain and oneSAM (sterile alpha motif) domain. STIM1 / GOK plays a role in mediating Ca2+influx following depletion of intracellular Ca2+stores. It acts as Ca2+sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca2+depletion, STIM1 / GOK translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca2+release-activated Ca2+(CRAC) channel subunit, TMEM142A / ORAI1. Transfection of STIM1 / GOK into cells derived from a rhabdoid tumor and from a rhabdomyosarcoma that do not express detectable levels of STIM1 can induce cell death, suggesting a possible role in the control of rhabdomyosarcomas and rhabdoid tumors. Defects in STIM1 are the cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 2 (IDTICED2) which is an immune disorder characterized by recurrent infections, impaired T-cell activation and proliferative response, decreased T-cell production of cytokines, lymphadenopathy, and normal lymphocytes counts and serum immunoglobulin levels.

        STIM1 References

        • Sabbioni S. et al., 1997, Cancer Res. 57: 4493-7.
        • Manji S.S. et al., 2000, Biochim. Biophys. Acta 1481: 147-55.
        • Williams R.T. et al., 2002, Biochim. Biophys. Acta. 1596: 131-7.
        • Spassova M.A. et al., 2006, Proc. Natl. Acad. Sci. USA. 103: 4040-5.
        • Parvez S. et al., 2008, FASEB J. 22: 752-61.

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