SPOCK1 Proteins, cDNA Clones Research Reagents

SPOCK1 (SPARC (Osteonectin), Cwcv And Kazal Like Domains Proteoglycan 1) is a protein coding gene located on human chromosome 5q31.2. SPOCK1 is also known as TIC1, SPOCK and TESTICAN. The human SPOCK1 gene encodes a 49124 Da protein containing 439 amino acids. The SPOCK1 protein is biasedly expressed in brain, prostate and other tissues. Among its related pathways are Integrin Pathway and ERK Signaling. SPOCK1 is related to calcium ion binding and cysteine-type endopeptidase inhibitor activity. SPOCK3 is an important paralog of SPOCK1 gene. SPOCK1 is associated with some diseases, including Deafness, Autosomal Recessive 101 and Gallbladder Cancer.

SPOCK1 Protein (1)

    SPOCK1 cDNA Clone (26)

    BC030691.2
    NM_009262.3

    SPOCK1 Lysate (1)

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      SPOCK1 Background

      Osteonectin, also known as SPOCK1, is an extracellular heparan/chondroitin sulfate proteoglycan. Members of this family are known as testicans, also called SPOCKs. They are characterized structurally by an N-terminal testican-specific domain, a follistatin-like region, a calcium-binding domain, a thyroglobulin-like domain, and an acidic C-terminal domain with two putative glycosaminoglycan attachment sites. SPOCKs are enriched in brain and have been shown to regulate neuronal attachment and outgrowth. They contain inhibitory regions in several domains targeted to different classes of protease, and in some cases may act as protease inhibitors. Osteonectin contains 1 Kazal-like domain and 1 thyroglobulin type-1 domain. Up to now, little is known about osteonectin’s function. It may play a role in cell-cell and cell-matrix interactions. Osteonectin also may contribute to various neuronal mechanisms in the central nervous system.

      SPOCK1 References

      • Alliel P.M., et al.,(1993), Testican, a multidomain testicular proteoglycan resembling modulators of cell social behaviour. Eur. J. Biochem. 214:347-350.
      • Marr H.S., et al., (1997), Endothelial cell expression of testican mRNA.Endothelium 5:209-219.
      • Ota T., et al.,(2004), Complete sequencing and characterization of 21,243 full-length human cDNAs.Nat. Genet. 36:40-45.

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