SP1 Antibodies, cDNA Clones Research Reagents

SP1 (Sp1 Transcription Factor), located on 12q13.13, is a Protein Coding gene. The gene produces an 80693 Da protein composed of 785 amino acids. The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The transcription factor SP1 is a DNA-binding protein that interacts with a variety of gene promoters containing GC-box elements. Depletion of Sp1 increases the sensitivity of cells to DNA damage, whereas overexpression of Sp1 can drive cells into apoptosis. Disease such as Huntington's Disease is associated with SP1.

SP1 Antibody (1)

    SP1 cDNA Clone (15)

    SP1 qPCR Primer (1)

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    SP1 Background

    Sp1 (specificity protein 1) belongs to the 26 member strong Sp/KLF family of transcription factors. Sp1 is a well-known member of a family of transcription factors that also includes Sp2, Sp3, and Sp4, which are implicated in an ample variety of essentially biological processes and have been proven important in cell growth, differentiation, apoptosis, and carcinogenesis. Sp1 activates the transcription of many cellular genes that contain putative CG-rich Sp-binding sites in their promoters. Sp1 also has a role in the DNA damage response; at low levels of DNA damage, Sp1 is phosphorylated by ATM and localizes to double-strand break sites where it facilitates DNA double-strand break repair. Depletion of Sp1 increases the sensitivity of cells to DNA damage, whereas overexpression of Sp1 can drive cells into apoptosis. In response to a variety of stimuli, Sp1 can be regulated through proteolytic cleavage by caspases and/or degradation.

    SP1 References

    • Vizcaíno C, et al. (2015) Sp1 transcription factor: A long-standing target in cancer chemotherapy. Pharmacol Ther 152 111-124.
    • Torabi B, et al. (2018) Caspase cleavage of transcription factor sp1 enhances apoptosis. Apoptosis 23 (1): 65-78.
    • O'Connor L, et al. (2016) The role of the ubiquitously expressed transcription factor sp1 in tissue-specific transcriptional regulation and in disease. Yale J Biol Med 89 (4): 513-525.
    • Beishline K, et al. (2015) Sp1 and the 'hallmarks of cancer'. Febs j 282 (2): 224-258.

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