Sonic Hedgehog Proteins, Antibodies, cDNA Clones Research Reagents

SHH (Sonic Hedgehog Signaling Molecule) is a protein coding gene located on human chromosome 7q36.3. SHH is also known as TPT, HHG1, HLP3, HPE3, SMMCI, ShhNC, TPTPS and MCOPCB5. The human SHH gene encodes a 49607 Da protein containing 462 amino acids. The SHH protein is biasedly expressed in stomach, urinary bladder and other tissues. Among its related pathways are Development_Hedgehog and PTH signaling pathways in bone and cartilage development and Signaling by GPCR. SHH is related to calcium ion binding. IHH is an important paralog of SHH gene. SHH is associated with some diseases, including Solitary Median Maxillary Central Incisor and Holoprosencephaly 3.

Sonic Hedgehog Protein (4)

    Sonic Hedgehog Antibody (2)

      Sonic Hedgehog cDNA Clone (26)


      Sonic Hedgehog Lysate (4)

        Sonic Hedgehog Background

        Sonic HedgeHog, also known as sonic hedgehog protein, belongs to the hedgehog family. It cannot be detected in adult tissues while can be found in fetal intestine, liver, lung, and kidney. Sonic HedgeHog is a protein that is vital in guiding the early embryo. It has been associated as the major inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Sonic HedgeHog intercellular signal is essential for a various patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Sonic HedgeHog binds to the patched receptor, which functions in association with smoothened, to activate the transcription of target genes. In the absence of sonic HedgeHog, patched receptor represses the constitutive signaling activity of smoothened. Sonic HedgeHog also regulates another factor, the gli oncogene. Defects in sonic hedgehog can cause microphthalmia isolated with coloboma type 5, triphalangeal thumb-polysyndactyly syndrome and holoprosencephaly type 3.

        Sonic Hedgehog References

        • Ericson J, et al. (1997) Graded sonic hedgehog signaling and the specification of cell fate in the ventral neural tube. Cold Spring Harb Symp Quant Biol. 62:451-66.
        • Marigo V, et al. (1996) Regulation of patched by sonic hedgehog in the developing neural tube. Proc Natl Acad Sci. 93(18):9346-51.
        • Stone DM, et al. (1996) he tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature. 384:129-34.

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