SMURF2 Antibodies, cDNA Clones Research Reagents

SMURF2 (SMAD Specific E3 Ubiquitin Protein Ligase 2) is a protein coding gene located on human chromosome 17q23.3-q24.1. The human SMURF2 gene encodes an 86196 Da protein containing 748 amino acids. The SMURF2 protein is ubiquitously expressed in lung, testis and other tissues. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Signaling by GPCR. SMURF2 is related to identical protein binding and ubiquitin-protein transferase activity. SMURF1 is an important paralog of SMURF2 gene. SMURF2 is associated with some diseases, such as Hepatitis C Virus.

SMURF2 Antibody (1)

    SMURF2 cDNA Clone (14)

    NM_022739.3

    SMURF2 qPCR Primer (1)

    SMURF2 Background

    Loss of SMURF2 either by small interfering RNA/short hairpin RNA (siRNA/shRNA) or by overexpression of a catalytically inactive mutant causes KRAS degradation, whereas overexpression of wild-type SMURF2 enhances KRAS stability. silencing SMURF2 (SMAD specific E3 ubiquitin protein ligase 2) promoted EMT in HPDE6c7 normal pancreas cells and overexpression of SMURF2 inhibited TGF-beta-mediated EMT in the cells.

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