Smad5 Proteins, Antibodies, cDNA Clones Research Reagents

All Smad5 reagents are produced in house and quality controlled, including 3 Smad5 Antibody, 30 Smad5 Gene, 2 Smad5 Lysate, 2 Smad5 Protein, 2 Smad5 qPCR. All Smad5 reagents are ready to use.

Smad5 Protein (2)

    Smad5 Antibody (3)

      Smad5 cDNA Clone (30)

      Smad5 Lysate (2)

        Smad5 Background

        SMAD5 is a member of the SMAD family. Members of this family mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD5 is involved in the TGF-beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. It is also involved in cell signalling and modulates signals of bone morphogenetic proteins (BMP's). The binding of ligands causes the oligomerization and phosphorylation of the SMAD5 protein. SMAD5 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase.

        Smad5 References

        • Vinayagam A. et al., 2011, Sci Signal. 4 (189): rs8.
        • Sangadala S. et al., 2007, J Biomol Struct Dyn. 25 (1): 11-23.
        • Riggins GJ. et al., 1996, Nat Genet. 13 (3): 347-9.

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