Smad3 Proteins, Antibodies, cDNA Clones Research Reagents

SMAD3 (SMAD Family Member 3) is a protein coding gene located on human chromosome 15q22.33. SMAD3 is also known as LDS3, LDS1C, MADH3, JV15-2, HSPC193 and HsT17436. The human SMAD3 gene encodes a 48081 Da protein containing 425 amino acids. The SMAD3 protein is ubiquitously expressed in urinary bladder, ovary and other tissues. Among its related pathways are Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer and Signal transduction_PKA signaling. SMAD3 is related to DNA-binding transcription factor activity and sequence-specific DNA binding. SMAD2 is an important paralog of SMAD3 gene. SMAD3 is associated with some diseases, including Loeys-Dietz Syndrome 3 and Familial Thoracic Aortic Aneurysm And Aortic Dissection.

Smad3 Protein (1)

    Smad3 Antibody (1)

      Smad3 cDNA Clone (30)

      Smad3 Lysate (1)

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        Smad3 Background

        SMAD3 belongs to the SMAD family. Members of this family mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD3 is involved in cell signalling. It modulates signals of activin and TGFβ's. Binding of SMAD3 with SMAD4 enables its transmigration into the nucleus where it forms complexes with other proteins and acts as a transcription factor. SMAD3 is a receptor-regulated SMAD (R-SMAD). In mice, mutation of SMAD3 has been linked to colorectal adenocarcinoma, increased systemic inflammation, and accelerated wound healing. Increased SMAD3 activity has been implicated in the pathogenesis of scleroderma. Smad3 is also a multifaceted regulator in adipose physiology and the pathogenesis of obesity and type 2 diabetes.

        Smad3 References

        • Tan. et al., 2011, Diabetes. 60 (2): 464-76.
        • Yang X. et al., 1999, Nat Cell Biol. 1 (5): 260-6.
        • Zhu Y. et al., 1998, Cell. 94 (6): 703-14.
        • Feng X. et al., 1996, Nature. 383 (6596): 168-72.

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