Smad2 Proteins, Antibodies, cDNA Clones Research Reagents

SMAD2 (SMAD Family Member 2) is a protein coding gene located on human chromosome 18q21.1. SMAD2 is also known as JV18, MADH2, MADR2, JV18-1, hMAD-2 and hSMAD2. The human SMAD2 gene encodes a 52306 Da protein containing 467 amino acids. The SMAD2 protein is ubiquitously expressed in thyroid, testis and other tissues. Among its related pathways are Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer and Signaling by GPCR. SMAD2 is related to DNA-binding transcription factor activity and transcription factor binding. SMAD3 is an important paralog of SMAD2 gene. SMAD2 is associated with some diseases, including Buschke-Ollendorff Syndrome and Osteopoikilosis.

Smad2 Protein (1)

    Smad2 Antibody (2)

      Smad2 cDNA Clone (30)

      Smad2 Lysate (1)

        Smad2 Background

        SMAD2 is a member of the SMAD family. Members of this family mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD2 mediates the signal of the TGF-beta, and therefore regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. SMAD2 is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. SMAD2 is the downstream signal transducers of TGF-beta-1 in human dental pulp cells. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. Phosphorylated SMAD2 is able to form a complex with SMAD4 or SARA. These complexes accumulate in the cell nucleus, where they are directly participating in the regulation of gene expression.

        Smad2 References

        • Feng. et al., 2002, Mol Cell. 9 (1): 133-43.
        • Zhu Y. et al., 1997, J Biol Chem. 272 (15): 10035-40.
        • Zi Z. et al., 2012, FEBS Lett. 586 (14): 1921-8.

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