SIRP gamma/SIRPG Proteins, Antibodies, cDNA Clones Research Reagents

All SIRP gamma/SIRPG reagents are produced in house and quality controlled, including 3 SIRP gamma/SIRPG Antibody, 28 SIRP gamma/SIRPG Gene, 5 SIRP gamma/SIRPG Lysate, 5 SIRP gamma/SIRPG Protein, 1 SIRP gamma/SIRPG qPCR. All SIRP gamma/SIRPG reagents are ready to use.

SIRP gamma/SIRPG Protein (5)

    SIRP gamma/SIRPG Antibody (3)

      SIRP gamma/SIRPG cDNA Clone (28)

      NM_018556.3
      BC064532

      In expression vector

      In lentiviral vector

      XM_001113667.2

      SIRP gamma/SIRPG qPCR Primer (1)

      SIRP gamma/SIRPG Lysate (5)

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        SIRP gamma/SIRPG Background

        Signal-regulatory protein gamma (SIRPG/SIRP gamma) also known as CD172 antigen-like family member B, CD172g, and CD172g antigen, is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. SIRPG/SIRP gamma/CD172g is probable immunoglobulin-like cell surface receptor. On binding with CD47, SIRPG can mediate cell-cell adhesion. SIRPG/SIRP gamma is engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation. SIRPG/SIRP gamma/CD172g is detected in liver, and at very low levels in brain, heart, lung, pancreas, kidney, placenta and skeletal muscle. Expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD2+ cells, and all activated NK cells. This cytokine is mainly present in the paracortical T-cell area of lymph nodes, with only sparse positive cells in the mantle and in the germinal center of B-cell follicles. In the thymus, SIRPG is primarily expressed in the medulla on mature T-lymphocytes that have undergone thymic selection.

        SIRP gamma/SIRPG References

        • Meador JA, et al. (2011) p53-independent downregulation of histone gene expression in human cell lines by high- and low-let radiation. Radiat Res. 175(6): 689-99.
        • Reddy MV, et al. (2011) Association between type 1 diabetes and GWAS SNPs in the southeast US Caucasian population. Genes Immun. 12(3): 208-12.
        • Kawasaki M, et al. (2009) Changes in the gene expression of peripheral blood mononuclear cells during the menstrual cycle of females is associated with a gender bias in the incidence of systemic lupus erythematosus. Clin Exp Rheumatol. 27(2): 260-6.

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