SIGLEC6 Proteins, Antibodies, cDNA Clones Research Reagents

SIGLEC6 (Sialic Acid Binding Ig Like Lectin 6) is a protein coding gene located on human chromosome 19q13.41. SIGLEC6 is also known as CD327, CD33L, OBBP1, CD33L1, CD33L2 and CDW327. The human SIGLEC6 gene encodes a 49913 Da protein containing 453 amino acids. The SIGLEC6 protein is biasedly expressed in placenta and lung. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. SIGLEC6 is related to carbohydrate binding. ENSG00000268500 is an important paralog of SIGLEC6 gene. SIGLEC6 is associated with Non-Gestational Choriocarcinoma.

SIGLEC6 Protein (1)

    SIGLEC6 Antibody (1)

      SIGLEC6 cDNA Clone (13)


      SIGLEC6 qPCR Primer (1)

      SIGLEC6 Lysate (1)

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        SIGLEC6 Background

        SIGLEC6, also known as CD327, belongs to the immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family. SIGLEC6 is a sialic acid recognizing protein expressed at high levels in placenta (cyto- and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine. SIGLEC6 localizes in various compartments such as membrane fraction, extracellular region and so on. SIGLEC6 may show increasing expression human labor and following childbirth, it has been speculated that this expression helps to slow the tempo of human labor. Interestingly, expression of SIGLEC6 is further upregulated in pre-eclampsia, which appears to be a uniquely human disease.

        SIGLEC6 References

        • Winn VD. et al., 2009, Endocrinology. 150 (1): 452-62.
        • Davila S. et al., 2010, Genes Immun. 11 (3): 232-8.
        • Lam KK. et al., 2011, J Biol Chem. 286 (43): 37118-27.

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