SHP2 Proteins, Antibodies, cDNA Clones Research Reagents

PTPN11 (Protein Tyrosine Phosphatase Non-Receptor Type 11) is a protein coding gene located on human chromosome 12q24.13. PTPN11 is also known as CFC, NS1, JMML, SHP2, BPTP3, PTP2C, METCDS, PTP-1D, SH-PTP2 and SH-PTP3. The human PTPN11 gene encodes a 68011 Da protein containing 593 amino acids. The PTPN11 protein is ubiquitously expressed in brain, fat and other tissues. Among its related pathways are RET signaling and Interleukin-11 Signaling Pathway. PTPN11 is related to protein domain specific binding and protein tyrosine phosphatase activity. PTPN6 is an important paralog of PTPN11 gene. PTPN11 is associated with some diseases, including Noonan Syndrome 1 and Juvenile Myelomonocytic Leukemia.

SHP2 Protein (1)

    SHP2 Antibody (2)

      SHP2 cDNA Clone (32)

      NM_002834.5

      In cloning vector

      BC008692
      NM_001330437.1

      In expression vector

      SHP2 Lysate (1)

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        SHP2 Background

        SHP2, also known as PTPN11, belongs to the protein-tyrosine phosphatase(PTP) family, non-receptor class 2 subfamily. PTPs catalyze the removal of phosphate groups from tyrosine residues by the hydrolysis of phosphoric acid monoesters. They dephosphorylate EGFR, JAK2 and TYK2 kinases, promoting oncogenic transformation. SHP2 is widely expressed, with highest levels in heart, brain, and skeletal muscle. SHP2 acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. It also dephosphorylates ROCK2 at Tyr-722 resulting in stimulation of its RhoA binding activity.

        SHP2 References

        • Ganju R K, et al. (2000) Beta-chemokine receptor CCR5 signals through SHP1, SHP2, and Syk. J Biol Chem. 275(23):17263-8.
        • Yin T, et al. (1997) Molecular characterization of specific interactions between SHP-2 phosphatase and JAK tyrosine kinases. J Biol Chem. 272(2):1032-7.
        • Kontaridis MI, et al. (2006) PTPN11 (Shp2) mutations in LEOPARD syndrome have dominant negative, not activating, effects. J Biol Chem. 281(10):6785-92.

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