SerpinD1 Proteins, Antibodies, cDNA Clones Research Reagents

All SerpinD1 reagents are produced in house and quality controlled, including 8 SerpinD1 Antibody, 26 SerpinD1 Gene, 2 SerpinD1 IP Kit, 2 SerpinD1 Lysate, 2 SerpinD1 Protein, 2 SerpinD1 qPCR. All SerpinD1 reagents are ready to use.

SerpinD1 Protein (2)

    SerpinD1 Antibody (8)

      SerpinD1 cDNA Clone (26)

      NM_000185.3
      NM_008223.3

      SerpinD1 Lysate (2)

        SerpinD1 Background

        SerpinD1, also known as heparin cofactor II, is a member of Serpin superfamily of the serine proteinase inhibitors. HCII is a glycoprotein in human plasma that inhibits thrombin and chymotrypsin, and the rate of inhibition of thrombin is rapidly increased by Dermatan sulfate (DS), heparin (H) and glycosaminoglycans(GAG). The stimulatory effect of glycosaminoglycans on the inhibition is mediated, in part, by the N-terminal acidic domain of HCII. Interestingly, a C-terminal His-tagged recombinant HCII exhibits enhanced activity of thrombin inhibition. It has been suggested that HCII plays an unique and important role in vascular homeostasis, and accordingly mutations in this gene or congenital HCII deficiency is potentially associated with thrombosis. HCII specifically inhibits thrombin action at the site of vascular wall injury and HCII-thrombin complexes have been detected in human plasma. HCII protects against thrombin-induced vascular remodeling in both humans and mice and suggest that HCII is a predictive biomarker and therapeutic target for atherosclerosis. SerpinD1 also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.

        SerpinD1 References

        • Rau JC, et al. (2009) Heparin cofactor II in atherosclerotic lesions from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study. Exp Mol Pathol. 87(3): 178-83.
        • Aihara K, et al. (2009) Heparin cofactor II as a novel vascular protective factor against atherosclerosis. J Atheroscler Thromb. 16(5): 523-31.

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