SerpinA3 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

SERPINA3 (Serpin Family A Member 3) is a protein coding gene located on human chromosome 14q32.13. SERPINA3 is also known as ACT, AACT, GIG24 and GIG25. The human SERPINA3 gene encodes a 47651 Da protein containing 423 amino acids. The SERPINA3 protein is biasedly expressed in liver, gall bladder and other tissues. Among its related pathways are Folate Metabolism and Response to elevated platelet cytosolic Ca2+. SERPINA3 is related to serine-type endopeptidase inhibitor activity. SERPINA9 is an important paralog of SERPINA3 gene. SERPINA3 is associated with some diseases, including Malignant Fibrous Histiocytoma and Alpha-1-Antitrypsin Deficiency.

SerpinA3 Protein (1)

    SerpinA3 Antibody (8)

      SerpinA3 ELISA Kit & Match Antibody ELISA Pair Set (2)

      SerpinA3 cDNA Clone (26)

      NM_001085.4
      XM_005562128.1

      SerpinA3 qPCR Primer (1)

      SerpinA3 Lysate (1)

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        SerpinA3 Background

        SerpinA3, also known as Alpha 1-antichymotrypsin (AACT), is a plasma alpha globulin glycoprotein, and is a member of serpin superfamily of the serine protease inhibitors consisting of at least 35 members. SerpinA3 has been demonstrated to inhibit the activity of certain serine proteases, such as cathepsin G found in neutrophils, and chymases present in mast cells, by inducing a major conformational rearrangement, and thus protects some tissues from damage caused by proteolytic enzymes. This enzyme is produced primarily in the liver, and is identified as an acute-phase inflammatory protein. SerpinA3 deficiency has been associated with liver disease, and mutations of this gene have been observed in patients with Parkinson disease and chronic obstructive pulmonary disease. Besides, ACT gene polymorphism has been implicated with Alzheimer’s disease (AD), cerebral amyloid angiopathy (CAA), as well as stroke, since SerpinA3 is a major constituent of the plaques in AD and an inhibitor of amyloid beta peptide degradation.

        SerpinA3 References

        • Nilsson, L.N. et al., 2001, J. Neurosci. 21: 1444-1451.
        • Ikari, Y. et al., 2001, J. Biol. Chem. 276: 11798-11803.
        • Vila, N. et al., 2000, Stroke. 31: 2103-2105
        • Eriksson, S. et al., 1995, Proc. Natl. Acad. Sci. USA. 92: 2313-2317.
        • Skeel, A. et al., 2001, J. Biol. Chem. 276: 21932-21937.

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