SELL/CD62L Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All SELL/CD62L reagents are produced in house and quality controlled, including 24 SELL/CD62L Antibody, 4 SELL/CD62L ELISA, 41 SELL/CD62L Gene, 7 SELL/CD62L Lysate, 7 SELL/CD62L Protein, 3 SELL/CD62L qPCR. All SELL/CD62L reagents are ready to use.

SELL/CD62L Protein (7)

    SELL/CD62L Antibody (24)

      SELL/CD62L ELISA Kit & Match Antibody ELISA Pair Set (4)

      SELL/CD62L cDNA Clone (41)


      In expression vector

      In lentiviral vector


      SELL/CD62L Lysate (7)

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        SELL/CD62L Background

        L-selectin (SELL), also known as CD62L, is a key adhesion molecule that regulates both the migration of leukocytes at sites of inflammation and the recirculation of lymphocytes between blood and lymphoid tissues. It belongs to the selectin family of proteins, and consisting of a large, highly glycosylated, extracellular domain, a single spanning transmembrane domain and a small cytoplasmic tail. L-selectin is the only selectin expressed on leukocytes and mediates a number of leukocyte-endothelial interactions. L-selectin acts as a "homing receptor" for leukocytes to enter secondary lymphoid tissues via high endothelial venules. Ligands present on endothelial cells will bind to leukocyte expressing L-selectin, slowing leukocyte trafficking through the blood, and facilitating entry into a secondary lymphoid organ at that point. L-selectin-mediated lymphocyte recirculation is required for maintaining the appropriate tissue distribution of lymphocyte subpopulations including naïve and effector subsets such as regulatory T cells. In addition, L-selectin-mediated entry into peripheral lymph nodes is required for optimal induction of lymphocyte homeostatic proliferation during lymphopenia. Importantly, L-selectin has been shown to have both adhesive and signaling functions during leukocyte migration. L-selectin has also been shown to mediate leukocyte recruitment during chronic inflammatory and autoimmune diseases and thus is a potential therapeutic target for drug development.

        SELL/CD62L References

        • Smalley DM, et al. (2005) L-selectin: mechanisms and physiological significance of ectodomain cleavage. J Cell Mol Med. 9(2): 255-66.
        • Grailer JJ, et al. (2009) L-selectin: role in regulating homeostasis and cutaneous inflammation. J Dermatol Sci. 56(3): 141-7.

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