SCF Proteins, Antibodies, cDNA Clones Research Reagents

KITLG (KIT Ligand, also known as SF; MGF; SCF; SLF; DCUA; FPH2; FPHH; KL-1; Kitl; SHEP7; DFNA69), located on 12q21.32, is a Protein Coding gene. The gene produces a 30899 Da protein composed of 273 amino acids. KITLG and its receptor, KIT, function in hematopoiesis, melanogenesis, and gametogenesis. Diseases such as Hyperpigmentation With Or Without Hypopigmentation, Familial Progressive and Deafness, Autosomal Dominant 69 are associated with KITLG. The related pathways of KITLG include RET signaling and Signaling by GPCR.

SCF Protein (3)

    SCF Antibody (7)

      SCF cDNA Clone (41)


      In cloning vector

      In lentiviral vector


      SCF Lysate (2)

        SCF Background

        Similar to Kit ligand precursor (C-kit ligand), also known as Stem cell factor (SCF), Mast cell growth factor (MGF), or Hematopoietic growth factor KL. SCF/C-kit ligand is the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. SCF/C-kit ligand stimulates the proliferation of mast cells. This protein can augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. It may act synergistically with other cytokines, probably interleukins SCF/C-kit ligand is the ligand for the tyrosine kinase receptor c-kit, which is expressed on both primitive and mature hematopoietic progenitor cells. In vitro, SCF/C-kit ligand synergizes with other growth factors, such as granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor, and interleukin-3 to stimulate the proliferation and differentiation of cells of the lymphoid, myeloid, erythroid, and megakaryocytic lineages. In vivo, SCF/C-kit also synergizes with other growth factors and has been shown to enhance the mobilization of peripheral blood progenitor cells in combination with G-CSF. In phase I/II clinical studies administration of the combination of SCF and G-CSF resulted in a two- to threefold increase in cells that express the CD34 antigen compared with G-CSF alone.

        SCF References

        • McNiece IK, et al. (1995) Stem cell factor. J Leukoc Biol. 58(1): 14-22.
        • Besmer P, et al. (1993) The kit-ligand (steel factor) and its receptor c-kit/W: pleiotropic roles in gametogenesis and melanogenesis. Dev Suppl. 1993:125-37.
        • Mekori YA, et al. (1993) IL-3-dependent murine mast cells undergo apoptosis on removal of IL-3. Prevention of apoptosis by c-kit ligand. J Immunol. 151(7): 3775-84.

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