SAP/SH2D1A Proteins, Antibodies, cDNA Clones Research Reagents

SH2D1A (SH2 Domain Containing 1A) is a protein coding gene located on human chromosome Xq25. SH2D1A is also known as LYP, SAP, XLP, DSHP, EBVS, IMD5, XLPD, MTCP1, XLPD1 and SAP/SH2D1A. The human SH2D1A gene encodes a 14187 Da protein containing 128 amino acids. The SH2D1A protein is biasedly expressed in lymph node, spleen and other tissues. Among its related pathways are Immune response Role of DAP12 receptors in NK cells and Tyrosine Kinases / Adaptors. SH2D1A is related to SH3/SH2 adaptor activity. SH2D1B is an important paralog of SH2D1A gene. SH2D1A is associated with some diseases, including Lymphoproliferative Syndrome, X-Linked, 1 and Lymphoproliferative Syndrome.

SAP/SH2D1A Protein (1)

    SAP/SH2D1A Antibody (3)

      SAP/SH2D1A cDNA Clone (30)

      SAP/SH2D1A qPCR Primer (1)

      SAP/SH2D1A Background

      SH2 domain-containing protein 1A (SH2D1A / SAP) is a 128 amino acid protein, containing a single Src homology 2 (SH2) domain, flanked by 5 amino acids at the N-terminus and 25 amino acids at the C-terminus. The absence of a catalytic domain and the presence of an SH2 domain suggest that SH2D1A regulates one or more signal transduction pathways. SH2D1A interacts with signaling lymphocytic activation molecule (SLAM), which is a transmembrane protein expressed on the surface of activated T and B cells. SH2D1A (SAP) interacts via its SH2 domain with a motif (TIYXXV) present in the cytoplasmic tail of the cell-surface receptors, including CD150 / SLAM, CD84, CD229 / Ly-9, and CD244 / 2B4. SH2D1A was expressed in EBV-carrying, tumor phenotype representative (type I), but not in EBV-carrying lymphoblastoid cell line (LCL)-like (type III) or EBV-negative Burkitt lymphoma (BL) lines. It has been supposed to be related to the X-linked lymphoproliferative disease which is also known as Duncan's disease or Purtilo syndrome.

      SAP/SH2D1A References

      • Morra M, et al. (2005) Defective B cell responses in the absence of SH2D1A. PNAS. 102 (13): 4819-23.
      • Morra M, et al. (2001) Characterization of SH2D1A Missense Mutations Identified in X-linked Lymphoproliferative Disease Patients. The Journal of Biological Chemistry. 276: 36809-16.
      • Hron JD, et al. (2004) SH2D1A Regulates T-dependent Humoral Autoimmunity. JEM. 200 (2): 261-6.

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