S100A4 Proteins, Antibodies, cDNA Clones Research Reagents

S100A4 (S100 Calcium Binding Protein A4) is a protein coding gene located on human chromosome 1q21.3. S100A4 is also known as 42A, 18A2, CAPL, FSP1, MTS1, P9KA and PEL98. The human S100A4 gene encodes a 11729 Da protein containing 101 amino acids. The S100A4 protein is broadly expressed in lung, bone marrow and other tissues. Among its related pathways are Ca, cAMP and Lipid Signaling. S100A4 is related to identical protein binding. S100A2 is an important paralog of S100A4 gene. S100A4 is associated with some diseases, including Bile Duct Adenocarcinoma and Small Intestine Adenocarcinoma.

S100A4 Protein (5)

    S100A4 Antibody (3)

      S100A4 cDNA Clone (30)

      S100A4 Lysate (3)

        S100A4 Background

        S100A4, also known as metastasis-associated protein Mtsl, belongs to the family of small calcium-binding S100 proteins containing two EF-hand calcium-binding motifs. In humans at least 20 S100 family members that are distributed tissue specifically have been identified, and are involved in a number of cellular processes as transducers of calcium signal. S100A4 is a symmetric homodimer, and undergoes a relatively large conformational change upon the typical EF-hand binding calcium, which is necessary for S100A4 to interact with its protein targets and generate biological effects. It can bind the already known targets p53, F-actin, liprin β, myosin heavy chain II, and prevent their phosphorylation and multimerization. It has been demonstrated that S100A4 is directly involved in tumor metastasis including cell motility, invasion, apoptosis, angiogenesis and differentiation, and appears to be a metastasis factor and a molecular marker for clinical prognosis. Multiple alternatively spliced variants encoding the same protein have been identified.

        S100A4 References

        • Ambartsumian N. et al., 1995, Gene. 159: 125-30.
        • Marenholz I. et al., 2004, Biochem Biophys Res Commun. 322: 1111-22.
        • Helfman DM. et al., 2005, Br J Cancer. 92: 1955-8.
        • Saleem M. et al., 2006, Proc Natl Acad Sci. 103: 14825-30.
        • Boye K. et al., 2008, Int J Cancer. 123: 1301-10.
        • Garrett SC. et al., 2006, J Biol Chem. 281: 677-80.
        • Kriajevska M. et al., 2002, J Biol Chem. 277: 5299-335.

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