S100A13 Proteins, Antibodies, cDNA Clones Research Reagents

S100A13 (S100 Calcium Binding Protein A13) is a protein coding gene located on human chromosome 1q21.3. The human S100A13 gene encodes a 11471 Da protein containing 98 amino acids. The S100A13 protein is broadly expressed in heart, fat and other tissues. S100A13 is related to calcium ion binding and lipid binding. S100A11 is an important paralog of S100A13 gene. S100A13 is associated with some diseases, including Conjunctival Intraepithelial Neoplasm and Psoriasis 7.

S100A13 Protein (2)

    S100A13 Antibody (7)

      S100A13 cDNA Clone (17)

      NM_001024210.1

      In expression vector

      In lentiviral vector

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      S100A13 Background

      S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that the protein is 100% soluble in ammonium sulfate at neutral pH. Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from theneural crest, chondrocytes, macrophages, dendritic cells, etc. S100 proteins have been implicated in a variety of intracellular and extracellular functions. They are involved in regulation of protein phosphorylation, transcription factors, the dynamics of cytoskeleton constituents, enzyme activities, cell growth and differentiation, and the inflammatory response. Protein S100-A13, also known as S100 calciumbinding protein A13, is a member of the S-100 family. It contains two EF-hand domains. S100A13 binds two calcium ions per subunit and one copper ion. Binding of one copper ion does not interfere with calcium-binding. S100A13 is required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine. S100A13 plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway.

      S100A13 References

      • Mandinova A. et al., 2003, J Cell Sci. 116: 2687-96.
      • Arnesano F. et al., 2005, Angew Chem Int Ed. 44: 6341-4.
      • Viemann D. et al., 2005, Blood. 105: 2955-62.
      • Nakatani Y. et al., 2005, Mediators Inflamm. 2005: 280-92.
      • Bjoerk P. et al., 2009, PLoS Biol. 7: E97-E97.

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