S100A10 Proteins, Antibodies, cDNA Clones Research Reagents

S100A10 (S100 Calcium Binding Protein A10) is a protein coding gene located on human chromosome 1q21.3. S100A10 is also known as 42C, P11, p10, GP11, ANX2L, CAL1L, CLP11, Ca[1] and ANX2LG. The human S100A10 gene encodes a 11203 Da protein containing 97 amino acids. The S100A10 protein is broadly expressed in colon, esophagus and other tissues. Among its related pathways are Dissolution of Fibrin Clot and Response to elevated platelet cytosolic Ca2+. S100A10 is related to calcium ion binding and lipid binding. S100A1 is an important paralog of S100A10 gene. S100A10 is associated with some diseases, including Trachea Leiomyoma and Barrett's Adenocarcinoma.

S100A10 Protein (1)

    S100A10 Antibody (3)

      S100A10 cDNA Clone (29)

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      S100A10 Background

      S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that the protein is 100% soluble in ammonium sulfate at neutral pH. Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from the neural crest, chondrocytes, macrophages, dendritic cells, etc. S1 proteins have been implicated in a variety of intracellular and extracellular functions. They are involved in regulation of protein phosphorylation, transcription factors, the dynamics of cytoskeleton constituents, enzyme activities, cell growth and differentiation, and the inflammatory response. Protein S100-A10, also known as Calpactin I light chain, Cellular ligand of annexin II, S100 calcium-binding protein A10, p10 protein, p11, ANX2LG and S100A10, is a member of the S100 family of small, dimeric EF hand-type Ca(2+)-binding proteins that generally modulate cellular target proteins in response to intracellular Ca(2+) signals. In contrast to all other S100 proteins, S100A10 is Ca(2+) insensitive because of amino acid replacements in its Ca(2+)-binding loops that lock the protein in a permanently active state. S100A10 forms a heterotetramer with annexin IIH and promotes carcinoma invasion and metastasis by plasminogen activation. S100A10 and annexin II contribute to the aggressive characteristics of anaplastic carcinoma, while playing a constitutive role in papillary carcinoma. S100A10 induces the dimerization of ANXA2 / p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target of tyrosine-specific kinase. S100A10 functions as a linker tethering certain transmembrane proteins to annexin A2 thereby assisting their traffic to the plasma membrane and/or their firm anchorage at certain membrane sites.

      S100A10 References

      • Gebhardt, C. et al., 2006, Biochem Pharmacol. 72 (11):1622-31.
      • Ito,Y. et al., 2007, Anticancer Res. 27 (4C):2679-83.
      • Svenningsson,P. et al., 2007, Curr Opin Pharmacol  7 (1):27-32.
      • Rescher,U. et al., 2008, Pflugers Arch. 455 (4):575-82.
      • Nonaka, D. et al., 2008, J. Cutan. Pathol. 35 (11): 1014-9.
      • Lim, SY. et al., 2008,  J Immunol. 181 (8): 5627-36.
      • Heibeck TH. et al., 2009, J. Proteome Res. 8:3852-61.

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