RTN4 Proteins, Antibodies, cDNA Clones Research Reagents

RTN4 (Reticulon 4) is a protein coding gene located on human chromosome 2p16.1. RTN4 is also known as ASY, NSP, NOGO, RTN-X, NSP-CL, RTN4-A, RTN4-C, RTN4-B1, RTN4-B2, NI220/250, Nbla00271 and Nbla10545. The human RTN4 gene encodes a 129931 Da protein containing 1192 amino acids. The RTN4 protein is ubiquitously expressed in fat, brain and other tissues. Among its related pathways are Neuroscience and Signaling by GPCR. RTN1 is an important paralog of RTN4 gene. RTN4 is associated with some diseases, including Kleptomania and Temporal Lobe Epilepsy.

RTN4 Protein (1)

    RTN4 Antibody (3)

      RTN4 cDNA Clone (40)


      In expression vector


      In expression vector


      In expression vector


      In expression vector

      RTN4 qPCR Primer (1)

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      RTN4 Background

      Reticulon-4, also known as Foocen, Neurite outgrowth inhibitor, Nogo protein, Neuroendocrine-specific protein, Neuroendocrine-specific protein C homolog, RTN-x, Reticulon-5 and RTN4, is a multi-pass membrane protein that contains one reticulon domain. Isoform 1 of RTN4 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 of RTN4 is widely expressed except for the liver. Isoform 3 of RTN4 is expressed in brain, skeletal muscle and adipocytes. Isoform 4 of RTN4 is testis-specific. Reticulon-4 / RTN4 is a developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Reticulon-4 / RTN4 regulates neurite fasciculation, branching and extension in the developing nervous system. Reticulon-4 / RTN4 is involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. It regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex. Isoform 2 of RTN4 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 of RTN4 inhibit BACE1 activity and amyloid precursor protein processing.

      RTN4 References

      • Yang J., et al., 2000, Cytogenet. Cell Genet. 88:101-102.
      • Prinjha R., et al., 2000, Nature 403: 383-384.
      • Tagami S., et al., 2000, Oncogene 19: 5736-5746.
      • Murayama K.S., et al., 2006, Eur. J. Neurosci. 24: 1237-1244.
      • Daub H., et al., 2008, Mol. Cell 31:438-448.
      • Choudhary C., et al., 2009, Science 325: 834-840.

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