RSPO1 Proteins, Antibodies, cDNA Clones Research Reagents

RSPO1 (R-Spondin 1) is a protein coding gene located on human chromosome 1p34.3. RSPO1 is also known as RSPO and CRISTIN3. The human RSPO1 gene encodes a 28959 Da protein containing 263 amino acids. The RSPO1 protein is biasedly expressed in endometrium, skin and other tissues. Among its related pathways are Signaling by GPCR and Signaling by Wnt. RSPO1 is related to signaling receptor binding and G protein-coupled receptor binding. RSPO3 is an important paralog of RSPO1 gene. RSPO1 is associated with some diseases, including Palmoplantar Hyperkeratosis With Squamous Cell Carcinoma Of Skin And 46, Xx Sex Reversal and Hermaphroditism.

RSPO1 Protein (4)

    RSPO1 Antibody (2)

      RSPO1 cDNA Clone (26)

      NM_001038633.2
      NM_138683.1

      RSPO1 Lysate (4)

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        RSPO1 Background

        RSPO1 gene is a member of the R-spondin family. It encodes RSPO1 which is known as a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, RSPO1 induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. This protein is an activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. RSPO1 acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. It also acts as a ligand for frizzled FZD8 and LRP6.

        RSPO1 References

        • Kamata T, et al. (2004) R-spondin, a novel gene with thrombospondin type 1 domain, was expressed in the dorsal neural tube and affected in Wnts mutants. Biochim Biophys Acta. 1676(1):51-62.
        • Ota T, et al. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 36(1):40-5.
        • Strausberg RL, et al. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci. 99(26):16899-903.

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