RON/CD136 Proteins, Antibodies, cDNA Clones Research Reagents

MST1R (Macrophage Stimulating 1 Receptor, also known as RON; SEA; PTK8; CD136; NPCA3; CDw136), located on 3p21.31, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 152241 Da protein composed of 1400 amino acids. This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. Diseases such as Nasopharyngeal Carcinoma 3 and Gastroesophageal Adenocarcinoma are associated with MST1R. The related pathways of MST1R include Sweet Taste Signaling and Signaling by GPCR.

RON/CD136 Protein (1)

    RON/CD136 Antibody (8)

      RON/CD136 cDNA Clone (1)


      In expression vector

      RON/CD136 qPCR Primer (1)

      RON/CD136 Lysate (1)

        RON/CD136 Background

        The tyrosine kinase receptor, macrophage-stimulating 1 receptor (MST1R), a c-met-related tyrosine kinase, also known as the Ron receptor or CD136, controls cell survival and motility programs related to invasive growth. As the tyrosine kinase receptor is comprised of an extracellular domain, MST1R protein contains the ligand-binding pocket and an intracellular region where the kinase domain is located. MST1R signaling may be involved in the regulation of macrophage and T-lymphocyte activation in vivo during injury. This assessment of gene expression indicates the importance of genetic factors in contributing to lung injury and points to strategies for intervention in the progression of inflammatory diseases. It had been shown that MST1R/CD136 plays a critical role in Ni-induced lung injury in mice. The overexpression of MSP, MT-SP1, and MST1R was a strong independent indicator of both metastasis and death in human breast cancer patients and significantly increased the accuracy of an existing gene expression signature for poor prognosis. Stimulation of MST1R leads to its transphosphorylation and the ultimate activation of numerous intracellular signaling pathways, such as the classical mitogen-activated protein kinase pathway, the phosphatidylinositol (PI)3-kinase pathway, and the JNK pathway.

        RON/CD136 References

        • Ronsin C, et al. (1993) A novel putative receptor protein tyrosine kinase of the met family. Oncogene. 8: 1195-1202.
        • McDowell SA, et al. (2002) The role of the receptor tyrosine kinase Ron in nickel-induced acute lung injury. Am J Respir Cell Mol Biol. 26(1): 99-104.
        • Angeloni D, et al. (2003) C to A single nucleotide polymorphism in intron 18 of the human MST1R (RON) gene that maps at 3p21.3. Mol Cell Probes. 17(2-3): 55-7.
        • Mallakin A, et al. (2006) Gene expression profiles of Mst1r-deficient mice during nickel-induced acute lung injury. Am J Respir Cell Mol Biol. 34(1): 15-27.
        • Welm AL, et al. (2007) The macrophage-stimulating protein pathway promotes metastasis in a mouse model for breast cancer and predicts poor prognosis in humans. Proc Natl Acad Sci U S A. 104(18): 7570-5.

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