RIPK1/RIP1 Antibodies, cDNA Clones Research Reagents

RIPK1 (Receptor Interacting Serine/Threonine Kinase 1) is a protein coding gene located on human chromosome 6p25.2. RIPK1 is also known as RIP, RIP1, AIEFL, IMD57, and RIP-1. The human RIPK1 gene encodes a 75931 Da protein containing 671 amino acids. The RIPK1 protein is ubiquitously expressed in gall bladder, colon and other tissues. Among its related pathways are Apoptosis Modulation and Signaling and Neuroscience. RIPK1 is related to identical protein binding and protein kinase activity. MAP3K9 is an important paralog of RIPK1 gene. RIPK1 is associated with some diseases, including Immunodeficiency 57 With Autoinflammation and Autoinflammation With Episodic Fever And Lymphadenopathy.

RIPK1/RIP1 Antibody (2)

    RIPK1/RIP1 cDNA Clone (30)

    RIPK1/RIP1 Background

    The receptor-interacting protein kinase 1 (RIPK1) is an essential signaling molecule in pathways for cell survival, apoptosis, and necroptosis. RIPK1-mediated cell proliferation through MCU is a central mechanism underlying colorectal cancer progression and may prove to be an important therapeutic target for colorectal cancer treatment. Parkin with Receptor-interacting protein kinase 1 (RIPK1) kinase, a key mediator of multiple signaling pathways activated by TNFR1 including NF-kappaB pathway. RIPK1-mediated mitochondrial dysfunction and oxidative stress play a crucial role in NP cells necroptosis and apoptosis during compression injury. The synergistic regulation of necroptosis and apoptosis may exert more beneficial effects on NP cells survival, and ultimately delaying or even retarding intervertebral disc degeneration.

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