RANK/TNFRSF11A Proteins, Antibodies, cDNA Clones Research Reagents

TNFRSF11A (TNF Receptor Superfamily Member 11a) is a protein coding gene located on human chromosome 18q21.33. TNFRSF11A is also known as FEO, OFE, ODFR, OSTS, PDB2, RANK, CD265, OPTB7, TRANCER and LOH18CR1. The human TNFRSF11A gene encodes a 66034 Da protein containing 616 amino acids. The TNFRSF11A protein is biasedly expressed in duodenum, colon and other tissues. Among its related pathways are TRAF Pathway and TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions. TNFRSF11A is related to cytokine binding. TNFRSF1B is an important paralog of TNFRSF11A gene. TNFRSF11A is associated with some diseases, including Osteopetrosis, Autosomal Recessive 7 and Familial Expansile Osteolysis.

RANK/TNFRSF11A Protein (5)

    RANK/TNFRSF11A Antibody (8)

      RANK/TNFRSF11A cDNA Clone (39)


      RANK/TNFRSF11A Lysate (5)

        RANK/TNFRSF11A Background

        TNFRSF11A is a member of the TNF-receptor superfamily. In mouse, it is also known as CD265. TNFRSF11A contains 4 TNFR-Cys repeats and is widely expressed with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. It is an essential mediator for osteoclast and lymph node development. TNFRSF11A and its ligand are important regulators of the interaction between T cells and dendritic cells. It can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. Defects in TNFRSF11A can cause familial expansile osteolysis (FEO). FEO is a rare autosomal dominant bone disorder characterized by focal areas of increased bone remodeling. Defects in TNFRSF11A also can cause Paget disease of bone type 2 (PDB2). PDB2 is a bone-remodeling disorder with clinical similarities to FEO. Defects in TNFRSF11A are the cause of osteopetrosis autosomal recessive type 7 which characterized by abnormally dense bone, due to defective resorption of immature bone.

        RANK/TNFRSF11A References

        • Darnay B G, et al. (1998) Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase. J Biol Chem. 273(32):20551-5.
        • Darnay B G, et al. (1999) Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif. J Biol Chem. 274(12):7724-31.
        • Galibert L, et al. (1998) The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily. J Biol Chem. 273(51):34120-7.

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